Heparinase-producing microorganism belonging to the genus bacill

Details Heparinase-producing microorganism belonging to the genus bacill Heparinase-producing microorganism belonging to the genus bacill

1991-11-27

1994-11-08

Marx, Irene

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Bacteria or actinomycetales; media therefor

435232, C12N 120, C12N 988

Patent

active

053626451

ABSTRACT:
A newly discovered microorganism is described that was isolated in biologically pure culture from soil and designated Bacillus sp. strain BH100 (FERM BP-2613 (FERM P-10408)). This strain is used in a new process for production of extracellular heparinase. Additionally a new heparinase having an optimum temperature for activity in the range of 45.degree. to 50.degree. C. is disclosed.

REFERENCES:
Yang et al., J. Biol. Chem. 260(3): 1849-1857 (1985).
Karbassi et al., Chemical Abstracts 92(2): 229, abstract No. 176342b and Can. J. Microbiol. 26(3): 377-384 (1980).
Linhardt et al., Applied Biochemistry and Biotechnology 12(2): 135-176 (1986).
Nakamura et al., Journal of Clinical Microbiology 26(5): 1070-1071 (1988).
Bohmer et al., J. of Biol. Chem. 265(23): 13609-13617 (1990).
Nader et al., J. Biol. Chem. 265(28): 16807-16813 (1990).

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