Heparin-selective polymeric membrane electrode

Details Heparin-selective polymeric membrane electrode Heparin-selective polymeric membrane electrode

1993-08-16

1995-09-26

Niebling, John

Chemistry: electrical and wave energy

Apparatus

Electrolytic

204403, 435817, 435288, G01N 2726

Patent

active

054531713

ABSTRACT:
An anion exchange membrane for ionic macromolecules, specifically heparin, which is formed of a polymeric matrix material and an anion exchange material suitable for heparin detection can be employed in an electrochemical sensor arrangement to directly measure the concentration of heparin ions in blood or blood fluid. Potentiometric response to heparin has been observed with membranes comprising 30-70 wt. % polymeric matrix material, such as polyvinyl chloride, 0.1-12 wt. % quaternary ammonium salt, such as tridodecyl methyl ammonium chloride, and 30-70 wt. % of a plasticizer, such as dioctyl sebacate. Moreover, a solid state sensor employs tridodecyl methyl ammonium chloride (TDMAC) dissolved in a polymeric compound, such as silicone rubber, to form a membrane which is responsive to heparin concentration.

REFERENCES:
patent: 5165952 (1992-11-01), Solomon et al.
patent: 5183549 (1993-02-01), Joseph et al.

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