Heparin derivatives having antimetastatic activity

Details Heparin derivatives having antimetastatic activity Heparin derivatives having antimetastatic activity

1998-03-31

2000-10-10

Fonda, Kathleen K.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 21, A61K 31725, C08B 3710

Patent

active

061302104

ABSTRACT:
Heparin derivatives are disclosed that may be used to inhibit formation of metastases. One series of heparin derivatives of the invention are N-acylated with monocarboxylic acids or dicarboxylic acids and have molecular weights from about 1000 Daltons to about 30,000 Daltons. Another series of heparin derivatives of the invention have average molecular weights ranging from about 1000 to 3000 daltons, and are optionally N-acylated with residues from aliphatic monocarboxylic or dicarboxylic acids.

REFERENCES:
patent: 4816446 (1989-03-01), Feller et al.
patent: 4933326 (1990-06-01), Bianchini et al.
patent: 4990502 (1991-02-01), Lormeau et al.
patent: 5541166 (1996-07-01), Parish et al.
patent: 5795860 (1998-08-01), Witt et al.

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