Heparin-binding growth factor (HBGF) polypeptides

Details Heparin-binding growth factor (HBGF) polypeptides Heparin-binding growth factor (HBGF) polypeptides

1997-08-07

1999-03-02

Spector, Lorraine

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Hormone or other secreted growth regulatory factor,...

530300, 530350, 530399, 530850, 435 694, 930120, A61K 3818

Patent

active

058767304

ABSTRACT:
Substantially pure heparin-binding growth factor polypeptides (HBGFs), nucleic acids encoding the HBGFs and antibodies which bind to the HBGFs of the invention are provided. The HBGF polypeptides are useful in methods for the induction of bone, cartilage and tissue formation, growth and development of the endometrium and in the acceleration of wound healing. HBGF is related to Connective Tissue Growth Factor (CTGF).

REFERENCES:
patent: 5408040 (1995-04-01), Grotendorst et al.
Brigstock et al., J. Biological Chemistry 272:20275-20282, 1997.
G.R. Grotendorst, Cytokine Growth Factor Reviews 8(3):171-179, 1997.
Brigstock et al., J. Reprod. Fert. 85:747-758, 1989.
G.Y. Kim et al., Biology of Reproduction 52:561-571, 1995.
Campochiaro et al., "Retinal Pigment Epithalial Cells Produce PDGF-like Proteins and Secrete them into their Media", Exp. Eye Res., (1989) 49:217-227
Shimokado et al., "A Significant Part of Macrophage-Derived Growth Factor Consists of at Least Two Forms of PDGF", Cell, 43:277-286, Nov.1985.
Matsuoka et al., "Two peptides related to platelet-derived growth factor are present in human wound field", Proc. Natl. Acad. Sci. USA, vol. 86, pp. 4416-4420, Jun. 1989.
Ryseck at al., "Structure, Mapping and Expression of fisp-12, a Growth Factor-inducible Gene Encoding a Secreted Cysteine-rich Protein", Cell, Vol. 2 pp. 225-233, May 1991.

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