Heparin- and sulfatide-binding peptides from the type I repeats

Details Heparin- and sulfatide-binding peptides from the type I repeats Heparin- and sulfatide-binding peptides from the type I repeats

1991-12-06

1994-10-18

Cashion, Jr., Merrell C.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

15 to 23 amino acid residues in defined sequence

530327, 530328, 530329, 530330, A61K 3700, A61K 3702, C07K 500, C07K 700

Patent

active

053570413

ABSTRACT:
The present invention relates to peptides from the three type I repeats of human endothelial cell thrombospondin, which bind to sulfated glycoconjugates including heparin and sulfatide. Such peptides are useful in glycoconjugate binding pharmaceutical compositions and in a method for binding glycoconjugates in a subject.

REFERENCES:
Prater et al., J. Cell Biol., vol. 112, pp. 1031-1040, (1991).
Roberts et al., J. Biol. Chem., vol. 260, No. 16, pp. 9405-9411, 5 Aug. 1985.
Bornstein et al., J. Biol. Chem, vol. 266, No. 20, pp. 12821-12824, 15 Jul. 1991.
Tuszynski, George P., et al. "Biological Activities of Peptides and Peptide Analogues Derived from Common Sequences Present in Thrombospondin, Properdin, and Malarial Proteins", J. Cell Biology, vol. 116, No. 1, (Jan. 1992) pp. 209-218.
Guo, Neng-hua, et al. "Heparin- and Sulfatide-binding Peptides from the Type I Repeats of Human Thrombospondin Promote Melanoma Cell Adhesion", Proc. Natl. Acad. Sci., vol. 89, No. 7, (Apr. 1, 1992) pp. 3040-3044.
Guo, Neng-hua, et al. "Heparin-binding Peptides from the Type I Repeats of Thrombospondin: Structural Requirements for Heparin Binding and Promotion of Melanoma Cell Adhesion and Chemotaxis", J. Biol. Chem., vol. 267, No. 27, (Sep. 25, 1992) pp. 19349-19355.
Cardin et al, Arteriosclerosis, vol. 9, pp. 21-32 (1989).
Rich et al, Science, vol. 249:1574-1577, (1990).
Prater et al, J. Cell Biol. vol. 112, pp. 1031-1040 (1991).
Zabrenetzky et al, Cancer Res., vol. 50, pp. 5937-5942 (1990).
Roberts et al, J. Biol. Chem. 260, 9405-9411 (1985).
Funahashi et al, Anal, Biochem. 126, 414-421 (1982).
Danilov et al, Exp. Cell Res. 182, 186-196 (1989).
Todaro et al, Proc. Natl. Acad. Sci USA 77, 5258-5262 (1980).
Roberts et al, J. Cell Biol. 104, 131-139 (1987).
Taroboletti et al, J. Biol. Chem. 265, 12253-12258 (1990).
Bornstein et al, J. Biol. Chem. 266, 12821-12824 (1991).
Jackson et al, Physiol. Rev. 71, 481-539, (1991).
Blackburn et al, J. Biol. Chem. 259, 939-941 (1984).
Cygler et al, Science 252, 442-445 (1991).
Sturgeon et al, Carbohydr. Res. 103, 213-219 (1982).
Holt et al, J. Biol. Chem. 264, 12138-12140 (1989).
Roberts, Cancer Res. 48, 6785-6792 (1988).
Kaesberg et al, J. Clin. Invest. 83, 994-1001 (1989).

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