Heparanase-derived peptides for vaccination of tumor patients

Details Heparanase-derived peptides for vaccination of tumor patients Heparanase-derived peptides for vaccination of tumor patients

2004-05-18

2010-11-30

Rawlings, Stephen L (Department: 1643)

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

8 to 10 amino acid residues in defined sequence

Reexamination Certificate

active

07842782

ABSTRACT:
Disclosed is a vaccine against diseases, particularly tumor diseases, being associated with an enhanced heparanase expression and/or activity, wherein the vaccine contains a heparanase peptide, which binds to a HLA molecule.

REFERENCES:
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patent: WO 03/006645 (2003-01-01), None
UniProt™ Database Accession No. Q9Y251 (Sequence Version 1, Nov. 1, 1999).
Rammensee et al., “SYFPEITHI: Database for MHC ligands and peptide motifs,”Immunogenetics, vol. 50, No. 3-4, Nov. 1999, pp. 213-219.
Moingeon, “Cancer Vaccines,”Vaccine, Butterworth Scientific, Guildford, GB, vol. 19, No. 11-12, 8 Dec. 8, 2001, pp. 1305-1326.
Vlodavsky et al., “Mammalian heparanase: involvement in cancer metastasis, angiogenesis and normal development,”Seminars in Cancer Biology, US, Apr. 2002, vol. 12, No. 2, pp. 121-129.
Krausa et al., “HLA-A2 polymorphism and immune functions,”European Journal of Immunogenetics, vol. 23, No. 4, 1996, pp. 261-274.

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