Heparanase activity neutralizing anti-heparanase monoclonal...

Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Monoclonal antibody or fragment thereof

Reexamination Certificate

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C424S142100, C424S146100

Reexamination Certificate

active

06946131

ABSTRACT:
A method of treating a condition associated with heparanase expression by administering a heparanase activity neutralizing monoclonal anti-heparanase antibody, the monoclonal anti-heparanase antibody being for neutralizing heparanase catalytic activity.

REFERENCES:
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Nakajima et al. J. Cell. Biochem. 1988, 36: 157-167.
Lider et al. J. Clin. Invest. 1989, 83: 752-756.
Parish et al. Int. J. Cancer 1987, 40: 511-518.

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