Heparanase-2 a member of the heparanase protein family

Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Hydrolase

Reexamination Certificate

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C435S004000, C435S006120, C435S069100, C435S183000, C435S192000, C435S252300, C435S320100, C435S325000, C536S023200, C536S023400, C536S023500, C530S350000

Reexamination Certificate

active

06872558

ABSTRACT:
Heparanase-2 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing heparanese-2 polypeptides and polynucleotides and diagnostic assays.

REFERENCES:
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patent: 6461848 (2002-10-01), Nakajima et al.
patent: WO 99 11798 (1999-03-01), None
patent: WO 99 21975 (1999-05-01), None
patent: WO 99 43830 (1999-09-01), None
patent: WO 200100643 (2001-01-01), None
E. McKenzie et al., “Cloning and Expression Profiling of hpa2, a Novel Mammallan Heparanase Family Member,” Biochemical and Biophysical Research Communications, vol. 276, No. 3, pp. 1170-1177, Oct. 5, 2000, XP002155087.
M.A. Kosir et al., “Degradation of Basement Membrane By Prostate Tumor Heparanase.” Journal of Surgical Research, vol. 81, No. 1, pp. 42-47, Jan. 1999, XP002155606, Abstract p. 45, right-hand column, line 13-p.46, left-hand column, line 18.
M.A. Kosir et al., “Human Prostate Carcinoma Cells Produce Extracellular Heparanase,” Journal of Surgical Research, vol. 67, No. 1, pp. 98-105, Jan. 1997, XP002155605, Abstract p. 102, right-hand column, line 23-p. 103, left-hand column, line 15.
R. Strausberg, “qg97h02.x1 Soares_NFL_T_GBC_S1Homo sapienscDNA clone IMAGE:1843155 3' , mRNA sequence,” Database EMBL 'Online! EMBL; ID A1222323, AC AC A1222323, Nov. 30, 1998, XP002155607.

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