Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1996-07-18
1999-07-27
Smith, Lynette F.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
536 232, 4353201, 435 691, C07H 2100, C07H 2104, C12N 1510
Patent
active
059292202
ABSTRACT:
The invention features a purified nucleic acid that encodes a member of the hepadnavirus family of cellular receptors. The receptor is a 170 kD cell surface glycoprotein, and is referred to as the p170 receptor. The pre-S domain of the duck hepatitis B virus envelope protein binds the p170 receptor at a major neutralizing epitope, within which are two basic amino acids required for virion-receptor interaction.
REFERENCES:
Kume et al., GenBank accession numbers M64402 J05742, A39521, and C39521, "Molecular cloning of the chicken and human glycine decarboxylase cDNAs . . . ", The Journal of Biological Chemistry, vol. 266, No. 5, pp. 3323-3329 Feb. 15, 1997.
Kuroki et al., "gp180, a host cell glycoprotein that binds duch hepatitis B virus particles, is encoded by a member of the carboxypeptidase gene family", The Journal of Biological Chemistry, vol. 270, No. 25, pp. 15022-15028 Jun. 23, 1995.
Grgacic et al., J.Virol. 68:7344-7350, 1994; "The Large Protein of Duck Hepatitis B Virus Is Phosphorylated in the Pre-S Domain".
Macrae et al., Virology 181:359-363, 1991; "Myristylation of a Duck Hepatitis B Virus Envelope Protein Is Essential for Infectivity but Not for Virus Assembly".
Persing et al., J. Virol. 61:1672-1677, 1987; "The preS1 Protein of Hepatitis B Virus Is Acylated at Its Amino Terminus with Myristic Acid".
Fernholz et al., Virology 197:64-73, 1993; "Minor Envelope Proteins of Duck Hepatitis B Virus Are Initiated at Internal Pre-S AUG Codons but Are Not Essential for Infectivity".
Summers et al., J. Virol. 65:1310-1317, 1991; "Morphogenetic and Regulatory Effects of Mutations in the Envelope Proteins of an Avian Hepadnavirus".
Sureau et al., J. Virol. 67:366-372, 1993; "Role of the Large Hepatitis B Virus Envelope Protein in Infectivity of the Hepatitis Delta Virion".
Budkowska et al., J. 67:4316-4322, 1993; "Hepatitis B Virus (HBV) Binding Factor in Human Serum: Candidate for a Soluble Form of Hepatocyte HBV Receptor".
Budkowska et al., J. Virol. 69:840-848, 1995; "Fibronectin of Human Liver Sinusoids Binds Hepatitis B Virus: Identification by an Anti-Idiotypic Antibody Bearing the Internal Image of the Pre-S2 Domain".
Hertogs et al., Virology 197:549-557, 1993; "Endoxin II, Present on Human Liver Plasma Membranes, Is a Specific Binding Protein of Small Hepatitis B Virus (HBV) Envelope Protein".
Mehdi et al., J. Virol. 68:2415-2424, 1994; "Hepatitis B Virus Surface Antigen Binds to Apolipoprotein H".
Neurath et al., J. Exp. Med. 176:1561-1569, 1992; "Cells Transfected with Human Interleukin 6 cDNA Acquire Binding Sites for the Hepatitis B Virus Envelope Protein".
Pontisso et al., J. Gen. Virol. 73:2041-2045, 1992; "the preS1 domain of hepatitis B virus and IgA cross-react in their binding to the hepatocyte surface".
Pugh et al., Virology 172:564-572, 1989; "Infection and Uptake of Duck Hepatitis B Virus by Duck Hepatocytes Maintained in the Presence of Dimethyl Sulfoxide".
Tuttleman et al., J. Virol. 58:17-25, 1986; "In Vitro Experimental Infection of Primary Duck Hepatocyte Cultures with Duck Hepatitis B Virus".
Mandart et al., J. Virol., 49:782-792, 1984: "Nucleotide Sequence of a Cloned Duck Hepatitis B Virus Genome: Comparison with Woodchuck and Human Hepatitis B Virus Sequences".
Norder et al., Virology, 198:489-503, 1994; "Complete Genomes, Phylogenetic Relatedness, and Structural Proteins of Six Strains of the Hepatitis B Virus, Four of Which Represent Two New Genotypes".
Wang et al., Nature, 323:508-13, 1986; "Structure, sequence and expression of the hepatitis delta (.delta.) viral genome".
Mason et al., J. Virol. 36:829-36, 1978; "Virus of Pekin Ducks with Structural and Biological Relatedness to Human Hepatitis B Virus".
Sprengel et al., J. Virol., 62:3832-39, 1988; "Isolation and Characterization of a Hepatitis B Virus Endemic in Herons".
Summers et al., Proc. Natl. Acad. Sci. USA, 75:4533-37, 1978; "A virus similar to human hepatitis B virus associated with hepatitis and hepatoma in woodchucks".
Marion et al., Proc. Natl. Acad. Sci. USA, 77:2941-45, 1980; "A virus in Beechey ground squirrels that is related to hepatitis B virus of humans".
Mason et al., Hepatology, 9:635-645, 1989; "Experimental Systems for the Study of Hepadnavirus and Hepatitis Delta Virus Infections".
Yuasa et al., Virology 181:14-21, 1991; "Peptide Mapping of Neutralizing and Nonneutralizing Epitopes of Duck Hepatitis B Virus Pre-S Polypeptide".
Chassot et al., Virology 192:217-223, 1993; "Fine Mapping of Neutralization Epitopes on Duck Hepatitis B Virus (DHBV) pre-S Protein Using Monoclonal Antibodies and Overlapping Peptides".
Lu et al., J. Virol. 70:2277-2285, 1996; Protease-Induced Infectivity of Hepatitis B Virus for a Human Hepatoblastoma Cell Line.
Li Jisu
Tong Shuping
Wands Jack R.
Brumback Brenda G.
Smith Lynette F.
The General Hospital Corporation
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