Hemostatically active vWF-containing preparation and process...

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Separation or purification

Reexamination Certificate

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C530S413000, C530S381000, C530S350000

Reexamination Certificate

active

07985846

ABSTRACT:
A process for preparing a hemostatically active preparation containing von Willebrand factor (vWF) from a fraction of human plasma by chromatographic purification of a vWF-containing plasma fraction on an anion-exchange material which has the anion-exchanging groups on grafted polymeric structures (tentacle materials), collecting a vWF-containing fraction, followed by purification of said fraction using gel permeation to prepare a purified thermally stable vWF-containing preparation; and heating the preparation for inactivating viruses.

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Mazurier et al “Development preclinique du concentre da facteur Willebrand vWF SD-35-dh”, Sang Thrombose Vaisseauz, vol. 11, No. Spezial, (Oct. 1999), XP-000925923, pp. 30-35.

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