Hemostatic thrombin paste composition

Details Hemostatic thrombin paste composition Hemostatic thrombin paste composition

1990-05-23

1997-01-21

Sayala, Chhaya D.

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Hydrolases

424529, 424530, 424531, 435214, A61K 3848, A61K 3516, C12N 974

Patent

active

055957358

ABSTRACT:
A hemostatic paste composition comprising a hemostatic effective amount of thrombin in a polyethylene glycol base which is preferably prepared by admixing an aqueous solution of thrombin and polyethylene glycol and freeze-drying the mixture to remove substantially all of the water to yield a viscous water soluble paste of fine particles of thrombin uniformly dispersed throughout the polyethylene glycol base, and methods of its use to provide hemostasis to a hemorrhaging site of a mammal.

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Remington's Pharmaceutical Sciences, Publishers: Mack Publishing Company, Easton, PA; 1975.
Rotoli et al., "Optimizing and Stabilizing Thrombin Activity", Chemical Abstracts 107: 35567r, 1986.

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