Hemostatic patch

Details Hemostatic patch Hemostatic patch

1995-06-07

1997-07-08

Kishore, Gollamudi S.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

424422, 424423, 424443, 424444, 424484, 424494, 514 2, 514 21, 514557, 514561, A61K 970

Patent

active

056458495

ABSTRACT:
A fibrogen-free substrate having as a hemostatic agent on a surface thereof a mixture of a clot-promoting amount of thrombin and an amount of epsilon aminocaproic acid (EACA) effective to accelerate the rate of blood clotting induced by the thrombin is useful as a hemostatic patch which is safe, inexpensive and which rapidly controls bleeding from a wound. A patch which rapidly stanches the flow of blood from a lesion on a parenchymal organ by pressing it against the surface of the organ for 3-5 minutes, is produced by applying thrombin, EACA and CaCl.sub.2 to a rigid sheet of biodegradable foam, such as an absorbable gelatin sponge, and compressing the dry sheet to produce a flexible sheet which conforms to the contour of the organ without the necessity of pre-moistening. The EACA raises the pH of the acidic fluid associated with the wound and thereby accelerates the activation of the thrombin.

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