Hemostatic compositions, devices and methods

Details Hemostatic compositions, devices and methods Hemostatic compositions, devices and methods

2006-08-22

2006-08-22

Spear, James M. (Department: 1615)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

C424S423000, C424S443000, C424S445000, C424S618000, C424S644000, C424S094640

Reexamination Certificate

active

07094428

ABSTRACT:
A hemostatic composition which comprises at least one procoagulant metal ion, such as silver (I) or mercury (II), and at least one procoagulant biopolymer, such as collagen, thrombin, prothrombin, fibrin, fibrinogen, heparinase, Factor VIIa, Factor VIII, Factor IXa, Factor Xa, Factor XII, von Willebrand Factor, a selectin, a procoagulant venom, a plasminogen activator inhibitor, glycoprotein IIb-IIIa, a protease, or plasma. The composition in the form of a paste, dough, glue, liquid, lyophilized powder or foam, may be provided, for application to a wound. A hemostatic device is also described which comprises a hemostatic composition as described above. The device may be in the form of, for example, a plug, bandage, gauze, cloth, tampon, membrane or sponge. Methods are also provided for prophylaxis or treatment of bleeding at a site by application to the site of the composition or device as described.

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Hiroshi Kaneko, et al., Mercury Compounds induce a rapid increase in procoagulant activity of monocyte-like U937 cells, British Journal of Haematology, vol. 87, pp. 87-93.
Christopher A. Goodwin, et al., Increased expression of procoagulant activity on the surface of human platelets exposed to heavy-metal compounds; vol. 308, pp. 15-21.

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