Hemostatic agent composed of collagen/gelatin and protamine

Details Hemostatic agent composed of collagen/gelatin and protamine Hemostatic agent composed of collagen/gelatin and protamine

1987-08-17

1988-06-07

Schain, Howard E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 8, 530354, 530356, 604368, 128DIG8, 128325, 1283355, A61K 3708, A61L 1501, A61L 1700, C08L 8906

Patent

active

047496894

ABSTRACT:
This invention relates to a hemostatic agent used in surgical operations, which can be produced in two ways: one blending collagen/gelatin with protamine, the other blending collagen/gelatin with protamine and a bi-functional cross-linking agent so as to make said collagen/gelatin have a covalent bond with said protamine. The produced hemostatic agent can stop bleeding within far less time than a conventional hemostatic agent made out of pure collagen.

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Coln, et al., (1983), Hemostatic Agents in Splenic Lacerations, American Journal of Surgery 145, pp. 256-259.
Abbott, et al., (1975), The Effectiveness and Mechanism of Collagen-Induced Topical Hemostasis; Surgery, vol. 78, No. 6, pp. 723-729.

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