Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Reexamination Certificate
2011-02-22
2011-02-22
Allen, Marianne P (Department: 1647)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
C435S007100, C435S007200, C435S007300, C435S007800, C435S326000, C424S130100, C424S178100, C424S184100
Reexamination Certificate
active
07893205
ABSTRACT:
A novel hemopoietin receptor gene (NR12) was successfully isolated by extracting motifs conserved among the amino acid sequences of known hemopoietin receptors and by using the predicted sequence. The NR12 gene encodes two forms of proteins, a transmembrane type and a soluble type. The expression of the NR12 gene was detected in tissues containing hematopoietic cells. NR12 is a novel hemopoietin receptor molecule involved in the regulation of immune system and hematopoiesis in vivo. Thus, NR12 is useful in the search for novel hematopoietic factors that functionally bind to the NR12 receptor, and in the development of therapeutic drugs for diseases associated with immunity or hematopoiesis.
REFERENCES:
patent: 6642360 (2003-11-01), Filvaroff et al.
patent: 6747137 (2004-06-01), Weinstock et al.
patent: 6756481 (2004-06-01), Chirica et al.
patent: 7045595 (2006-05-01), Maeda et al.
patent: 7250168 (2007-07-01), Light et al.
patent: 7411041 (2008-08-01), Chirica et al.
patent: 7482440 (2009-01-01), Maeda et al.
patent: 2003/0082734 (2003-05-01), Dowling et al.
patent: 2003/0125520 (2003-07-01), Maeda et al.
patent: 2003/0215838 (2003-11-01), Sprecher et al.
patent: 2006/0106201 (2006-05-01), Maeda et al.
patent: 2006/0166284 (2006-07-01), Light et al.
patent: 2006/0182743 (2006-08-01), Bilsborough
patent: 2007/0203328 (2007-08-01), Maeda et al.
patent: 2008/0019985 (2008-01-01), Light et al.
patent: 2008/0020965 (2008-01-01), Light et al.
patent: 2009/0029484 (2009-01-01), Maeda et al.
patent: 2009/0105457 (2009-04-01), Maeda et al.
patent: 2009/0105458 (2009-04-01), Maeda et al.
patent: 2009/0105459 (2009-04-01), Maeda et al.
patent: 2009/0111972 (2009-04-01), Maeda et al.
patent: 2010/0016552 (2010-01-01), Maeda et al.
patent: 2010/0055092 (2010-03-01), Hasegawa et al.
patent: 2010/0240096 (2010-09-01), Maeda et al.
patent: 2010/0240145 (2010-09-01), Maeda et al.
patent: 0 411 946 (1991-02-01), None
patent: 0 931 646 (1999-07-01), None
patent: 1 088 831 (2001-04-01), None
patent: 1 188 830 (2002-03-01), None
patent: 2005-532045 (2005-10-01), None
patent: WO 95/33059 (1995-12-01), None
patent: WO 97/15663 (1997-01-01), None
patent: WO 97/07215 (1997-02-01), None
patent: WO 97/12037 (1997-03-01), None
patent: WO99/67290 (1999-12-01), None
patent: WO 00/73451 (2000-12-01), None
patent: WO 00/75314 (2000-12-01), None
patent: WO 01/23556 (2001-04-01), None
patent: WO 01/85790 (2001-11-01), None
patent: WO 02/00721 (2002-01-01), None
patent: WO 02/29060 (2002-04-01), None
patent: WO 02/077230 (2002-10-01), None
patent: WO 03/060090 (2003-07-01), None
patent: WO 03/072740 (2003-09-01), None
patent: WO 2004/003140 (2004-01-01), None
patent: WO 2006/063864 (2006-06-01), None
patent: WO 2006/081573 (2006-08-01), None
patent: WO 2006/088855 (2006-08-01), None
patent: WO 2006/088955 (2006-08-01), None
patent: WO 2006/088956 (2006-08-01), None
patent: WO 2006/122079 (2006-11-01), None
patent: WO2007133816 (2007-11-01), None
Abbas et al, Cellular and Molecular Immunology, Second edition, W.B. Saunders Company, Philadelphia (1994).
Alexander et al., “Suckling defect in mice lacking the soluble haemopoietin receptor NR6”,Current Biology, vol. 9:605-608 (1999).
Baumgartner et al., “The role of the WSXWS equivalent motif in growth hormone receptor function”,Journal of Biological Chemistry, vol. 269:29094-29101 (1994).
Bepler et al., “A 1.4-Mb high-resolution physical map and contig of chromosome segment 11p15.5 and genes in LOH11A metastasis suppressor region”,Genomics, vol. 55:164-175 (1999).
Bork et al., “Go hunting in sequence databases but watch out for the traps”,Trends in Genetics, vol. 12:425-427 (1996).
Bork, “Powers and Pitfalls in Sequence Analysis: The 70% Hurdle”,Genome Research, vol. 10:398-400 (2000).
Cioffi et al., “Novel B219/OB receptor isoforms: Possible role of leptin in hematopoiesis and reproduction”,Nature Medicine, vol. 2:585-589 (1996).
Cosman et al., “A new cytokine receptor superfamily”,Trends Biochem. Sci., vol. 15:265-270 (1990).
Cosman, “The Hematopoietin Receptor Superfamily”,Cytokine, vol. 5:95-106 (1993).
Dillon et al., “Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice”,Nature Immunology, vol. 5:752-760 (2004).
Diveu et al., “GPL, a novel cytokine receptor related to gp130 and leukemia inhibitory factor receptor”,J. Biol. Chem., vol. 278:49850-49859 (2003).
Donaldson et al., “The murine IL-13 receptor α2: Molecular cloning, characterization, and comparison with murine IL-13 receptor α2”,The Journal of Immunology, vol. 161:2317-2324 (1998).
Gainford et al., “Leptin can induce proliferation, differentiation, and functional activation of hemopoietic cells”,Proc. Natl. Acad. Sci. USA, vol. 93:14564-14568 (1996).
Ghilardi et al., “A novel type I cytokine receptor is expressed on monocytes, signals proliferation, and activates STAT-3 and STAT-5”,J. Biol. Chem., vol. 27:16831-16836 (2002).
Hibi et al., “Molecular cloning and expression of an IL-6 signal transducer, gp130”,Cell, vol. 63:1149-1157 (1990).
Hilton et al., “Cloning of a murine IL-11 receptor α-chain; requirement for gp 130 for high affinity binding and signal transduction”,The EMBO Journal, vol. 13:4765-4775 (1994).
Hilton et al., “Cloning and characterization of a binding subunit of the interleukin 13 receptor that is also a component of the interleukin 4 receptor”, Proc. Natl. Acad. Sci. USA, 93:497-501 (1996).
Jabbour et al., “Expression of functional prolactin receptors in non-pregnant human endometrium: janus kinase-2, signal transducer . . . ”,J. Clin. Endocrinol. Metab., vol. 83(7):2545-2553 (1998).
Kernebeck et al., “The signal transducer gp130: solution structure of the carboxy-terminal domain of the cytokine receptor homology region”,Protein Science, vol. 8:5-12 (1999).
Mahairas et al., “Sequence-tagged connectors: A sequence approach to mapping and scanning the human genome”,Proc. Natl. Acad. Sci. USA, vol. 96:9730-9744 (1999).
Matsuno et al., “Treatment of rheumatoid synovitis with anti-reshaping human interleukin-6 receptor monoclonal antibody”,Arthritis&Rheumatism, vol. 41:2014-2021 (1998).
Matthews et al., “A receptor tyrosine kinase specific to hematopoietic stem and progenitor cell-enriched populations”,Cell, vol. 65:1143-1152 (1991).
Miyajima et al., “Cytokine receptors and signal transduction”,Annu. Rev. Immunol., vol. 10:295-331 (1992).
Miyazaki et al., “The integrity of the conserved ‘WS motif’ common to IL-2 and other cytokine receptors is essential for ligand binding and signal transduction”,EMBO J., vol. 10:3191-3197 (1991).
Murakami et al., “Critical cytoplasmic region of the interleukin 6 signal transducer gp130 is conserved in the cytokine receptor family”,Proc. Natl. Acad. Sci., vol. 88:11349-11353 (1991).
Nishimoto et al., “Improvement in Castleman's disease by humanized anti-interleukin-6 receptor antibody therapy”,Blood, vol. 95:56-61 (2000).
Nishimoto et al., “Toxicity, pharmacokinetics, and dose-finding study of repetitive treatment with the humanized anti-interleukin 6 receptor antibody MRA in rheumatoid arthritis. Phase I/II clinical study”,J. Rheumatology, vol. 30:1426-1435 (2003).
Oppmann et al., “Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12”,Immunity, vol. 13:715-725 (2000).
Ozaki et al., “Cytokine receptor pleiotropy and redundance”,J. Biol. Chem., vol. 277:29355-29356 (2002).
Parham et al., “A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rβ1 and a novel cytokine receptor subunit, IL-23R”,The Journal of Immunology, vol. 168:5699-5708 (2002).
Robb et al., “Structural Analysis of the Ge
Maeda Masatsugu
Yaguchi Noriko
Allen Marianne P
Chugai Seiyaku Kabushiki Kaisha
DeBerry Regina M
Fish & Richardson P.C.
LandOfFree
Hemopoietin receptor protein, NR12 does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Hemopoietin receptor protein, NR12, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Hemopoietin receptor protein, NR12 will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2624222