Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Reexamination Certificate
2007-07-31
2007-07-31
Gambel, Phillip (Department: 1644)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
C530S387900, C424S130100, C424S139100
Reexamination Certificate
active
10651250
ABSTRACT:
Novel proteins providing the new approach to development of the drugs and pesticides with the use or application of a hemolytic activity, and novel proteins having the following properties and the genes encoding thereof are provided:(1) having hemolytic activity;(2) having a molecular weight of about 50,000 Da (determined by SDS gel electrophoresis);(3) having an amino acid sequence represented by any of SEQ ID NO 1 to SEQ ID NO 3 as a partial amino acid sequence; and(4) having an amino acid sequence represented by SEQ ID NO 5 as the full amino acid sequence.
REFERENCES:
Nagai et al. Biosci. Biotechnol. Biochem. 2002. 66(1):97-102.
Lederman et al. Molecular Immunology 1991, 28: 1171-1181.
Li et al. PNAS 1980. 77: 3211-3214.
G. Rottini, et al., “Purification and Properties of a Cytolytic Toxin in Venom of the JellyfishCarybdea marsupialis” Toxicon, vol. 33, No. 3, Mar. 1995, pp. 315-326.
L. Cariello, et al., “Isolation and partial characterization of rhizolysin, a high molecular weight protein with hemolytic activity, from the jellyfishRhizostoma pulmo” Toxicon, vol. 26, No. 11, 1988, pp. 1057-1065.
M. Tamkun, et al., “Isolation and partial characterization of a hemolytic and toxic protein from the nematocyst venom of the Portuguese Man-of-War,Physalia physalis” Biochemistry and Biophysical Acta, vol. 667, No. 1, 1981, pp. 87-98.
H. Azuma, et al., “Platelet aggregation caused by a partially purified jellyfish toxin fromCarybdea rastonii” Toxicon, vol. 24, No. 5, 1986, pp. 489-899.
H. Nagai, et al., “Novel proteinaceous toxins from the box jellyfish (Sea Warp)Carybdea rastoni” Biochemical and Biophysical Research Communications, vol. 275, No. 2, Aug. 28, 2000, pp. 582-588.
Allison, et al., “Cloning and Characterization of a Prevotella Melaninogenica Hemolysin” Infect. Immun., vol. 65, No. 7, Jul. 1997, pp. 2765-2771.
Sato, A., “Toxins ofCarybdea rastonii” Ochanomizu Igaku Zasshi, 1985, vol. 33, No. 2, pp. 131-151. (abstract) Toxcenter [Bioscience on STN] Retrieved from: STN International, Columbus, OH, USA. Accession No. CA10321175714H.
Tamken, et al., “Isolation and Partial Characterization of a Hemolytic and Toxic Protein from the Nematocyst Venom of the Portuguese Man-of-War”Physalia physalis. 1981, Biochim. Biophys. Act, vol. 667, pp. 87-98.
Smith, et al., “The Challenges of Genome Sequence Annotation or ‘The devil is in the details’” 1997, Nature Biotechnol. vol. 15, pp. 1222-1223.
Doerks, et al., “Protein Annotation: Detective Work for Function Predication” 1998, Trends in Genetics, vol. 14, No. 6, pp. 248-250.
Nagai, et al., “Novel Proteinaceous Toxins from the Box Jellfish (Sea Wasp)Carybdea Rastonii” 2000, Biochem. Biophys. Res. Comm., vol. 275, pp. 582-588.
Zhang, et al., “Environment-Dependent residue contact energies for proteins” Mar. 2000, Proc. Natl. Acad. Sci., vol. 97, No. 6, pp. 2550-2555.
Nagai Hiroshi
Nakajima Terumi
Crowder Chun
Crowell & Moring LLP
Gambel Phillip
Suntory Limited
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