Hemolymphopoietic growth factors, process for purifying and prod

Details Hemolymphopoietic growth factors, process for purifying and prod Hemolymphopoietic growth factors, process for purifying and prod

1987-12-03

1993-11-23

Moezie, F. T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 2, 514 21, 530399, 530413, 530412, 530838, 4351723, 4352402, C07K 320, C07K 1506, A61K 3702

Patent

active

052644189

ABSTRACT:
This invention relates to hemolymphopoeitic growth factors (HLGF-1) that synergize with CSF-1, IL3 and GM-CSF and have pre-B cell potentiating activity. The invention also relates to a process for purifying such HLGF-1's from murine marrow cells and for producing such HLGF-1s by hosts transformed with recombinant DNA molecules comprising DNA sequences encoding the growth factor, and to methods of treatment and compositions characterized by HLGF-1s. These methods and agents are useful in immunoregulatory and hemopoietic applications and therapies.

REFERENCES:
patent: 4868119 (1989-09-01), Clark
Song et al., "Functional and Morphologic Characterization of a Cell Line Derived from Adherent Mouse Stromal Cells", Exp. Hematol, p. 106 (USA 1983).
Song et al., "Long-Term Hemopoiesis Supported by a Subclone Isolated from Murine Bone Marrow Stromal Cell Line TC-1", Exp. Hematol, p. 463 (USA 1984).
Mori et al., "Stimulation and Support of Haemopoietic Stem Cell Proliferation . . . ", J. Radiat, pp. 109-115 (USA 1981).
Friedenstein et al., "Stromal Cells Responsible for Transferring the Microenvironment of the Hemopoietic Tissues", Transplantation, pp. 331-340 (USA 1974).
Westen et al., "Association of Alkaline-Phosphatase-Positive Reticulum Cells in Bone Marrow . . . ", J. Exp. Med., pp. 919-937 (USA 1979).
Quesenberry et al., "Studies of the Control of Hemopoiesis in Dexter Cultures", Long-Term Bone Marrow Culture, pp. 171-193 (USA 1984).
Schofield, "The Relationship Between the Spleen Colony-Forming Cell and the Heemopoietic Stem Cell", Blood Cells, pp. 7-25 (USA 1978).
Toksoz et al., "The Regulation of Hemopoiesis in Long-Term Bone Marrow Cultures . . . ", Blood, pp. 931-936 (USA 1980).
Lanotte et al., "Histochemical and Ultrastructural Characteristics of a Cell Line . . . ", J. Cell Science, pp. 281-297 (Great Britain 1981).
Song et al., "Hemopoietic Factor Production by TC-1, A Dexter Derived Murine Marrow Adherent Cell Line", Blood, p. 141a (USA 1983).
Quesenberry et al., Blood, 65, Nal, 214-217, 1985.

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