Chemistry: physical processes – Physical processes – Crystallization
Patent
1978-09-25
1980-06-24
Marantz, Sidney
Chemistry: physical processes
Physical processes
Crystallization
73 1G, 73 19, 204 1T, 204195B, 204195P, 324 71R, 422 68, G01N 3316, G01N 2730, G01N 2740
Patent
active
042093007
ABSTRACT:
A system for obtaining a hemoglobin-oxygen equilibrium curve for a sample of concentrated hemoglobin solution or whole blood. Gaseous oxygen and/or nitrogen is used to oxygenate or deoxygenate the sample. The exchange takes place across a gas-receiving cup-shaped semipermeable membrane in a temperature-controlled chamber containing the sample, in an annular space defined between the cup-shaped gas-receiving membrane and the chamber wall. The rate of oxygen transport into and out of the sample is continuously calculated by means of a microcomputer. Simultaneously the solution pO.sub.2 is measured by means of a Clark electrode exposed to the sample. From the oxygen transport rate calculation and the pO.sub.2 measurement, the percent O.sub.2 saturation is calculated and is plotted against the change in pO.sub.2. Oxygen can be exchanged bidirectionally with the sample across the semipermeable membrane, which is positioned concentrically in a cylindrical sample cavity. The sample solution is maintained well-stirred by a magnetic stirrer provided in the cavity.
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Abstract, "An Instrument for the Automated Determination of the Hemoglobin-Oxygen Equilibrium Curve," by L. Thibault and R. Kusnetz, National Institutes of Health, Aug. 24, 1977.
Abstract, "An Instrument to Determine the Hemoglobin-Oxygen Equilibrium Curve Based on an Analytical Model for the Transport of Oxygen Across a Semi-Permeable Membrane," by L. E. Thibault, R. Kusnetz, R. M. Winslow & R. L. Berger, National Institutes of Health, May 15, 1978.
Marantz Sidney
The United States of America as represented by the Department of
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