Hemoglobin intramolecularly cross-linked with trivalent reagents

Details Hemoglobin intramolecularly cross-linked with trivalent reagents Hemoglobin intramolecularly cross-linked with trivalent reagents

1992-08-28

1994-03-01

Wityshyn, Michael G.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

530402, 530410, A61K 3514

Patent

active

052909190

ABSTRACT:
Stroma-free hemoglobin cross-linked with reagents that mimic 2,3-diphosphoglycerate and transform stroma-free hemoglobin into a physiologically competent oxygen carrier which is retained in vivo for adequate periods of time, and thus can be used in fluids for transporting oxygen is described.

REFERENCES:
patent: 4001401 (1977-01-01), Bonsen et al.
patent: 4529719 (1985-07-01), Tye
patent: 4584130 (1986-04-01), Bucci et al.
patent: 4600531 (1986-07-01), Walder
Shimizu et al., "Allosteric Effectors of Hemoglobin . . . ", Biochemistry, vol. 13, No. 4, 1974, pp. 809-814.
Bucci et al., "Hemoglobin Tetramers Stabilized with Poly Aspirins", Biomater., Artif. Cells, Immobilization Biotechnol. 20(2-4), 1992, pp. 243-252.
Cashon, R. et al., "Properties of Benzenetincarboxylic Acid . . . " Biomater. Artif. Cells, Immobilization Biotechnol. 19(2), 1991, p. 364 B1051592:109515.
Poillon, W. N. et al. "Deoxygenated Sickle Hemoglobin Modulation . . . " J. Biol. Chem., 260(26), 1985, pp. 13897-13900. Biosis 86:129432.
Banerjee et al., "Effect of Polycarboxylate Aminos on Hemoglobin", C.A. Acad. Sci., Ser. D, 277(11), 1973, pp. 963-966; CA 80(15):79315q.

Affiliated with

Also associated with

Rating

Hemoglobin intramolecularly cross-linked with trivalent reagents does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Hemoglobin intramolecularly cross-linked with trivalent reagents, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Hemoglobin intramolecularly cross-linked with trivalent reagents will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-578693