Hemoglobin-enzyme complexes

Details Hemoglobin-enzyme complexes Hemoglobin-enzyme complexes

1994-11-15

1997-02-25

Guzo, David

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

424 942, 424 944, 435189, 435192, 530402, 530829, A61K 3842, A61K 3854, A61K 3514, C07K 14805

Patent

active

056060254

ABSTRACT:
Crosslinked hemoglobin preparations having chemically bound thereto superoxide dismutase (SOD) and catalase are provided, for use as oxygen carrying rescusitative fluids, e.g. blood substitutes. The enzymes crosslinked to the hemoglobin effectively scavenge super oxide and hydrogen peroxide to improve the performance of the fluid in respect of ischemia-reperfusion injury risks.

REFERENCES:
patent: 4857636 (1989-08-01), Hsia
patent: 5250665 (1993-10-01), Kluger
patent: 5336493 (1994-08-01), Poznansky et al.
patent: 5352773 (1994-10-01), Kandler et al.
"Hemoglobin-Based Red Cell Substitutes", Robert M. Winslow, MD, (A book), The John's Hopkins University Press, 1992.
"Blood Substitutes and Oxygen Carriers" Thomas M. S. Chang (Editor), (A book), published by Marcel Dekker, New York, 1992.
Halliwell et al. "Free Radicals, Antioxidants, & Human Disease: Where Are We Now?" J. Lab. Clin. Med. 119(6) 598-620 1992.
Reilly et al. "Pharmacologic Approach to Tissue Injury Mediated by Free Radicals & Other Reactive Oxygen Metabolites" Am J. Surg. 161 488-503 1991 .

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