Hemoglobin-encapsulating liposome and method for making the same

Details Hemoglobin-encapsulating liposome and method for making the same Hemoglobin-encapsulating liposome and method for making the same

1995-12-01

1997-11-18

Kishore, Gollamudi S.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

A61K 9127

Patent

active

056885261

ABSTRACT:
A hemoglobin-encapsulating liposome having encapsulated thererin a hemoglobin solution having added thereto a substrate for an enzymatic reaction which produces reduced-form nicotinamide adenine dinucleotide (NADH) and/or reduced-form nicotinamide adenine dinucleotide phosphate (NADPH). Irreversible oxidation of hemoglobin with lapse of time is markedly suppressed.

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patent: 5039665 (1991-08-01), Markov
Szebeni, Biochemistry 24, p. 2827, 1985.
Okamoto Takeshi, Liposome Containing Hemoglobin and Preparation Thereof, Jul. 11, 1990, Patent Abstracts of Japan-JP-A-02 178 233.
Abstraact, AN 92-118330, Derwent Publications Ltd., London, Feb. 26, 1992.
Abstract, AN 75-68422W, Derwent Publications Ltd., London, Mar. 24, 1975.
Beissinger et al, Liposome-encapsulated Hemoglobin as a Red Cell Surrogate-Preparation Scale-up, Jul.-Sep. 1986, 58-63.
Abstract, AN 89-117245, Derwent Publications Ltd., London, Mar. 8, 1989.
Abstract, AN 87-259765, Derwent Publications Ltd., London, Aug. 5, 1987.

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