Hemoglobin-encapsulated liposome

Details Hemoglobin-encapsulated liposome Hemoglobin-encapsulated liposome

1995-06-14

1997-10-07

Kishore, Gollamudi S.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

264 41, 264 46, A61K 9127

Patent

active

056745281

ABSTRACT:
A hemoglobin-encapsulated liposome is provided. The hemoglobin-encapsulated liposome comprises a liposome and an enzymatically active hemoglobin solution encapsulated therein. The hemoglobin solution is supplemented with glucose; and at least one member selected from the group consisting of adenine, inosine, and adenosine triphosphate; and optionally, further with phosphoenol pyruvate. The thus supplemented hemoglobin solution encapsulated in the liposome exhibits an improved resistance to conversion to methemoglobin as well as an adequately regulated affinity for oxygen. Therefore, the hemoglobin-encapsulated liposome of the present invention is useful as a blood substitute.

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Beissinger et al, Liposome-encapsulated Hemoglobin as a Red Cell Surrogate--Preparation Scale-up, Jul.-Sep. 1986, 58-63.
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Okamoto Takeshi, Liposome Containing Hemoglobin and Preparation Thereof, Jul. 11, 1990, Patent Abstracts of Japan--JP-A-02 178 233.
Abstract, AN 92-118330, Derwent Publications Ltd., London, Feb. 26, 1992.
Abstract, AN 75-68422W, Derwent Publications Ltd., London, Mar. 24, 1975.
Szebeni et al, Biochemistry, "Encapsulation of Hemoglobin in Phospholipid Liposomes: Characterization and Stability", vol. 24, (1985), pp. 2827-2832 .

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