Hemoglobin assay for neonatal screening

Details Hemoglobin assay for neonatal screening Hemoglobin assay for neonatal screening

2004-09-22

2009-06-09

Gabel, Gailene R (Department: 1641)

Chemistry: analytical and immunological testing

Hemoglobin, myoglobin, or occult blood

C435S007100, C435S007250, C435S007920, C435S007940, C435S973000, C436S519000, C436S522000, C436S524000, C436S528000, C436S548000, C436S015000, C436S164000, C436S172000, C436S811000

Reexamination Certificate

active

07544513

ABSTRACT:
The present invention provides an assay, suitable for neonatal screening of hemoglobinopathies by quantitatively determining the presence of at least one pair of hemoglobin (Hb) variants, determining the ratio between the signals obtained from each variant; and, based on that ratio, determining whether the tested subject is afflicted or not.

REFERENCES:
patent: 6617158 (2003-09-01), Bohmer
patent: 6951760 (2005-10-01), Hofstraat
patent: 1 255 111 (2002-11-01), None
Rosenthal et al., Monoclonal antibody immunoassay for the identification of hemoglobin variants in neonatal screening, Screening 3: 67-76 (1994).
Moscoso et al., Peroxidase/Monoclonal antibody Conjugates for the Study of Hemoglopathies, Journal of Laboratory Analysis 7: 214-219 (1993)).
Turpeinen et al., Determination of Fetal Hemoglobin by Time-Resolved Immunofluorometric Assay (Clin. Chem. 38(10): 2013-2018 (1992).
Campbell et al., Detection of Hemoglobin Variants in Erythrocytes by Flow Cytometry, Cytometry 35: 242-248 (1999).
Moscoso et al., “Peroxidase/Monoclonal Antibody Conjugates for the Study of Hemoglobinopathies,”Journal of Clinical Laboratory Analysis, 1993, vol. 7, pp. 214-219, Wiley-Liss, Inc., New York, New York, U.S.A.
Rosenthal et al., “Monoclonal antibody immunoassay for the identification of hemoglobin variants in neonatal screening,”Screening, 1994, vol. 3, pp. 67-76, Elsevier Science Publishers B.V., London, England.

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