Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2005-12-13
2005-12-13
Low, Christopher S. F. (Department: 1614)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C514S731000, C514S734000, C514S054000
Reexamination Certificate
active
06974794
ABSTRACT:
There are provided biocompatible chemical compositions having oxygen transporting capability and comprising oxygen transporting molecules chemically bound to antioxidants, to form compositions capable of protecting a mammalian body from oxidative damage. An example of a composition according to the invention is hemoglobin covalently coupled to a 6-hydroxy chroman carboxylic acid, such as Trolox.
REFERENCES:
patent: 4001200 (1977-01-01), Bonsen et al.
patent: 4425334 (1984-01-01), Hunt
patent: 4831012 (1989-05-01), Estep
patent: 5099012 (1992-03-01), Mickle et al.
patent: 5290919 (1994-03-01), Bucci et al.
patent: 5532352 (1996-07-01), Pliura et al.
patent: 5606025 (1997-02-01), D'Agnillo et al.
patent: 5658879 (1997-08-01), Nho
patent: 5780060 (1998-07-01), Levy et al.
patent: 5789376 (1998-08-01), Hsia
patent: 6028066 (2000-02-01), Unger
patent: WO 97 00236 (1997-01-01), None
patent: WO 99 56723 (1999-11-01), None
“Inhibition of Lipid Peroxidation Promoted by Iron(III) and ascorbate”, abstract, Archives of Biochemistry and Biophysics, 1992, 297(2), 258-64.
Database Embase 'Online! Elsevier Science, Publishers, Amsterdam, NL HSIA J.C. et al: “Pharmacokinetic studies in the rat on a o-raffinose polymerized human hemoglobin.” Retrieved from STN Database accession No. 92299803 XP002140429 abstract & biomaterials, Artificial Cells, and Immobilization Biotechnology, (1992) 20/2-4 (587-595).
Database Embase 'Online! Elsevier science Publishers, Amsterdam, NL Mordente A. et al., “Antioxidant properties of 2, 3-dimethoxy-5-mthyl-6(10-hydroxydecyl)-1,4-benzoquinone (idebenone).” Retrieved from STN Database accession No. 1998044603 XP002140430 abstract & chemical research in Toxicology, (1998) 11/1 (54-63).
Database Chemabs 'Online! Chemical Abstracts service, Columbus, Ohio, US Chen, Hao et al.: “Protection by vitamin E, selenium, trolox C, ascorbic acid palmitate, acetylcysteine, coenzyme Q, beta-carotene, canthaxanthin, and (+)-catechi against oxidative damage to liver slices measured by oxidized heme proteins” retrieved from STN Database accession No. 121:26809 XP002140431 abstract & free radical Biol. Med. (1994), 16(4), 437-44.
Adamson James Gordon
McIntosh Greg Angus
Bereskin & Parr Micheline Gravelle
Hemosol LP
Kwon Brian-Yong S.
Low Christopher S. F.
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