Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Reexamination Certificate
2005-01-07
2008-09-02
Jiang, Shaojia Anna (Department: 1623)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
C536S004100, C536S018200
Reexamination Certificate
active
07419960
ABSTRACT:
Two hitherto unreported novel hemiterpene glycosides were isolated in substantially pure form from the root ofIlex pubescens. The chemical structures and some properties of these hemiterpenes have been elucidated. These hemiterpene glycosides possess anti-platelet aggregation activity more potent than those of salvianolic acid B and aspirin and may be used in pharmaceutical compositions in humans and mammals in need of such treatment.
REFERENCES:
patent: 4987125 (1991-01-01), Han et al.
Yang et al., “The vascular effects ofIlex pubescens”, Planta Medica, 1986, 52:262-265.
Han et al. “Anticoagulant Activity of Ilexoside D, a Triterpenoid Saponin fromIlex pubescens.” Archives of Pharmacal Research, 1993, 16(3):209-212.
Qin et al. A Study on the Chemical Constituents of the Leaves ofIlex pubescensHook et Arn varglaberChang. III. Elucidation of the Structure of Gladeride I. A New Lignan Compound.Acta Pharmaceutica Sinica, 1980, 15(11):669-673.
Yang et al. “The Vascular Effects ofIlex pubescens.” Planta Medica, 1986, 52:262-265.
Wang et al. “Effects of Ilex A Ingredient on Platelet Function and Shape.”Chinese Journal of Integrated Traditional and Western Medicine, 1985, 5(4):232-234.
Jiang et al. “A Lupane Triterpene and Two Caffeates fromRhoiptelea chiliantha.” Phytochemistry, 1995, 40(4):1223-1226.
Jiang, Z. H. “Two Diastereomeric Triterpene-Lignan Esters Having Dimeric Structure and Their Biosynthetically Related Triterpene Caffeate fromRhoiptelea chiliantha.” Tetrahedron Letters, 1994, 35(13):2031-2034.
Jiang et al. “Caffeoyl, Coumaroyl, Galloyl, and Hexahydroxydiphenoyl Glucoses fromBalanophora japonica.” Chem. Pharm. Bull., 2001, 49(7):887-892.
Jiang et al. “Dammarane-Type Triterpene Glycosides from the Leaves ofRhoiptelea chiliantha.” Chem. Pharm. Bull., 1999, 47(2):257-262.
Yu et al. “neo-Lignans and Hemiterpenoid from the Seeds ofArtabostrys hexapetalus(Annonaceae).”Journal of Chinese Pharmaceutical Sciences, 2002, 11(1):4-10.
Toyota et al. “New Glycosides from the Japanese fernHymenophyllum barbatum.” Chem. Pharm. Bull., 2002, 50(4):508-514.
Jiang et al. “Biflavanones, Diterpenes, and Coumarins from the Roots ofStellera chamaejasmeL.”Chem. Pharm. Bull., 50(1):137-139.
Zeng et al. “Studies on the Chemical Structures of Ilexolide A.” GaodengXuexiao Huaxue Xuebao, 1984,Chemical Journal of Chinese Universities, 5(4):503-507.
Qin et al. “Studies on the Chemical Constituents ofIlex pubescensHook et Am. II. The Structure of Ilexsaponin A.”Acta Chimica Sinica, 1987, 45:249-255.
Hidaka et al. “New Triterpene Saponins fromIlex pubescens.” Chem. Pharm. Bull., 1987, 35(2):524-529.
Hidaka et al. “A Triterpene and Saponin from Roots ofIlex pubescens.” Phytochemistry, 1987, 26(7):2023-2027.
Jiang et al. “Studies on the Chemical Constituents ofIlex publescens. III. Isolations and Identifications of Four Saponin Glycosides.”Zhongcaoyao, 1991, 22(7):291-294.
Jiang Zhihong
Li Min
Liu Liang
Liu Zhongqiu
Wang Jingrong
Hong Kong Baptist University
Jiang Shaojia Anna
Knobbe Martens Olson & Bear LLP
McIntosh, III Traviss C
LandOfFree
Hemiterpene glycosides with anti-platelet aggregation... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Hemiterpene glycosides with anti-platelet aggregation..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Hemiterpene glycosides with anti-platelet aggregation... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3986233