Hemicholinium lipids and use thereof

Details Hemicholinium lipids and use thereof Hemicholinium lipids and use thereof

1992-02-14

1993-03-23

Ramsuer, Robert W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

544158, 544173, 564292, A61K 31535, C07D26530, C07D26532

Patent

active

051964180

ABSTRACT:
Compounds of the present invention are those having the formula: ##STR1## where R is a linear or branched chain of 1 to 22 carbon atoms selected from the group consisting of alkyl, alkenyl or alkynyl or said C.sub.1 to C.sub.22 chains substituted with --SR.sub.3, --OR.sub.3, --NHR.sub.3, --CH.sub.3, or --C(O)OR.sub.2 where R.sub.2 is hydrogen or C.sub.1 to C.sub.6 alkyl; R.sub.1 is hydrogen, C.sub.1 to C.sub.6 alkyl, --SR.sub.3, --OR.sub.3, --NHR.sub.3, --NR'.sub.3 R.sub.3, or --C(O)OR.sub.2 where R.sub.2 is as previously defined; R.sub.3 and R'.sub.3 are the same or different and are hydrogen, C.sub.1 to C.sub.6 alkyl, alkylthioalkyl, alkoxyalkyl, aminoalkyl, aminoalkyl substituted with phenyl, substituted phenyl, benzoyl, substituted benzoyl, heteroaryl or substituted heteroaryl; R.sub.4 is hydrogen, C.sub.1 to C.sub.6 alkyl, or --C(O)OR.sub.2 where R.sub.2 is defined previously; R.sub.5 is hydrogen, C.sub.1 to C.sub.6 alkyl, phenyl, or substituted phenyl; R.sub.6 is hydrogen, C.sub.1 to C.sub.6 alkyl, phenyl, substituted phenyl, heterroaryl or substituted heteroaryl; m is an integer from 0 to 3; and n is an integer from 1 to 23.
The compounds provide useful methods of inhibiting carnitine palmitoyltransferase.

REFERENCES:
patent: 3225042 (1965-12-01), Dillard et al.
patent: 4670557 (1987-06-01), Su
Rekka et al., Chemical Abstracts, vol. 112 (1989) No. 35775q.
Lee et al., Chemical Abstracts, vol. 116 (1992) No. 250124q.
Gandour et al., Chemical Abstracts, vol. 110 (1988) No. 110640f.

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