Hemiasterlin derivatives and uses thereof

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C514S315000

Reexamination Certificate

active

07064211

ABSTRACT:
The present invention provides compounds having formula (I):and additionally provides methods for the synthesis thereof and methods for the use thereof in the treatment of cancer, wherein R1–R7, X1, X2, R, Q, and n are as defined herein.

REFERENCES:
patent: 5661175 (1997-08-01), Kashman et al.
patent: 5798355 (1998-08-01), Steiner et al.
patent: 6143721 (2000-11-01), Janssen et al.
patent: 6153590 (2000-11-01), Andersen et al.
patent: 40 16 994 (1991-11-01), None
patent: 10230874 (2004-01-01), None
patent: 8-73444 (1996-03-01), None
patent: WO 96/33211 (1996-10-01), None
patent: WO 97/43305 (1997-11-01), None
patent: WO 98/13375 (1998-04-01), None
patent: WO 99/31122 (1999-06-01), None
patent: WO 99/32509 (1999-07-01), None
patent: WO 01/18032 (2001-03-01), None
patent: WO 01/79167 (2001-10-01), None
patent: WO 03/008378 (2003-01-01), None
patent: WO 04/47615 (2004-06-01), None
patent: WO 04/48527 (2004-06-01), None
Anderson, et al., “Total Synthesis of (−) Hemiasterlin, A Structurally Novel Tripeptide that Exhibits Potent Cytotoxic Activity”,Tetrahedron Letters, 38(3): 317-320, 1997.
Bilson, et al., “The Design and Synthesis of Inhibitors of the Cysteinyl Protease, Der P I.”,Bioorganic&Medicinal Chemistry Letters, 8: 993-998, 1998.
Dragovich, et al., “Stucture-Based Design, Synthesis, and Biological Evaluation of Irreversible Human Rhinovirus 3C Protease Inhibitos. 1. Michael Acceptor Structure-Activity Studies”,J. Med. Chem. 41: 2806-2818, 1998.
Hauske, et al., “Design and Synthesis of Novel FKBP Inhibitors”,J. Med. Chem. 35: 4284-4296, 1992.
Nieman, et al., “Synthesis and Antimitotic/Cytotoxic Activity of Hemiasterlin Analogues”,J. Nat. Prod. 66: 183-189, 2003.
Jones, et al., “The use of norbornene derivatives in the synthesis of conformationally constrained peptides and pseud-peptides”,Letters in Peptide Science, 5(2-3): 171-173, 1998.
Copy of partial International Search Report for corresponding International Application No. PCT/US04/30921.
Database Caplus [online]; Chemical Abstracts Service, Columbus, Ohio, US; XP002249343; Database accession No. 125:33694 (DN); RN 177553-75-2.
Copy of International Search Report for related application No. PCT/US03/08888.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Hemiasterlin derivatives and uses thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Hemiasterlin derivatives and uses thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Hemiasterlin derivatives and uses thereof will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3652215

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.