Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2006-06-20
2006-06-20
Desai, Rita (Department: 1625)
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
C514S315000
Reexamination Certificate
active
07064211
ABSTRACT:
The present invention provides compounds having formula (I):and additionally provides methods for the synthesis thereof and methods for the use thereof in the treatment of cancer, wherein R1–R7, X1, X2, R, Q, and n are as defined herein.
REFERENCES:
patent: 5661175 (1997-08-01), Kashman et al.
patent: 5798355 (1998-08-01), Steiner et al.
patent: 6143721 (2000-11-01), Janssen et al.
patent: 6153590 (2000-11-01), Andersen et al.
patent: 40 16 994 (1991-11-01), None
patent: 10230874 (2004-01-01), None
patent: 8-73444 (1996-03-01), None
patent: WO 96/33211 (1996-10-01), None
patent: WO 97/43305 (1997-11-01), None
patent: WO 98/13375 (1998-04-01), None
patent: WO 99/31122 (1999-06-01), None
patent: WO 99/32509 (1999-07-01), None
patent: WO 01/18032 (2001-03-01), None
patent: WO 01/79167 (2001-10-01), None
patent: WO 03/008378 (2003-01-01), None
patent: WO 04/47615 (2004-06-01), None
patent: WO 04/48527 (2004-06-01), None
Anderson, et al., “Total Synthesis of (−) Hemiasterlin, A Structurally Novel Tripeptide that Exhibits Potent Cytotoxic Activity”,Tetrahedron Letters, 38(3): 317-320, 1997.
Bilson, et al., “The Design and Synthesis of Inhibitors of the Cysteinyl Protease, Der P I.”,Bioorganic&Medicinal Chemistry Letters, 8: 993-998, 1998.
Dragovich, et al., “Stucture-Based Design, Synthesis, and Biological Evaluation of Irreversible Human Rhinovirus 3C Protease Inhibitos. 1. Michael Acceptor Structure-Activity Studies”,J. Med. Chem. 41: 2806-2818, 1998.
Hauske, et al., “Design and Synthesis of Novel FKBP Inhibitors”,J. Med. Chem. 35: 4284-4296, 1992.
Nieman, et al., “Synthesis and Antimitotic/Cytotoxic Activity of Hemiasterlin Analogues”,J. Nat. Prod. 66: 183-189, 2003.
Jones, et al., “The use of norbornene derivatives in the synthesis of conformationally constrained peptides and pseud-peptides”,Letters in Peptide Science, 5(2-3): 171-173, 1998.
Copy of partial International Search Report for corresponding International Application No. PCT/US04/30921.
Database Caplus [online]; Chemical Abstracts Service, Columbus, Ohio, US; XP002249343; Database accession No. 125:33694 (DN); RN 177553-75-2.
Copy of International Search Report for related application No. PCT/US03/08888.
Kowalczyk James J.
Kuznetsov Galina
Schiller Shawn
Seletsky Boris M.
Spyvee Mark
Choate,Hall & Stewart LLP
Desai Rita
Eisai Co. Ltd.
Iarrell Brenda Herschbach
Lagneau Nadege M.
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