Hemiasterlin and geodiamolide TA

Details Hemiasterlin and geodiamolide TA Hemiasterlin and geodiamolide TA

1995-06-20

1997-08-26

Haley, Jacqueline

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514183, 540 1, 548495, A61K 3140, C07D20914

Patent

active

056611757

ABSTRACT:
Three cytotoxic peptides, the known compound Jaspamide and two new peptides, hemiasterlin (Compound 2) and geodiamolide TA (Compound 3), have been isolated from the sponge Hemiasterella minor. The structures of the three were determined by interpreting the NMR and mass spectra. Hemiasterlin (Compound 2) is a novel linear tripeptide embodying two unique, new natural amino acids and geodiamolide TA (Compound 3) is a newly discovered higher homolog of geodiamolides A-F.

REFERENCES:
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Talpir et al., Tetrahedron Letters, vol. 35, No. 25, pp. 4453-4456, 1994.

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