Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Hydrolase
Patent
1980-10-28
1983-06-28
Wiseman, Thomas G.
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Hydrolase
435814, 435816, 435212, 435219, 424 94, C12N 964, C12N 948, C12N 950, A61K 3754
Patent
active
043906303
ABSTRACT:
Novel fibrinolytic factors obtained from the salivary glands of Haementeria ghilianii. Proteins having molecular weights under about 100,000 are isolated from the salivary glands of H. ghilianii. The proteins show cathodic mobility in electrophoresis and uninhibited peptidase activity with fibrinogen in plasma.
REFERENCES:
Hamou Da, "Demonstration of an Enzyme Contributing to the Inhibition of the Coagulation of Blood Ingested by Hematokhageous Insect Rhodnius Prolixus."Arch. Inst. Pasteur Tunus 55:(1978) pp. 70-88.
Kelen et al., "Fibrmolytic Substance (Hementerin) of Brazillian Blood-Sucking Leeches, (Haementeria Lutzi) Haemostasis, 4(1) (1975) pp. 51-64.
Bagdy et al., "Hirudin" Methods in Enzymology vol. 45, (1976) pp. 669-678.
Otroshko et al., "A Study of Aspergillus Ochraceus Proteolytic System and its Plasmocoagulating and Fibrimolytic Activities" Mikrobiologiya 48(4) (1979) pp. 645-652.
Imshenetskii et al., "Application of the Tissue Culture Method for Assaying the Toxicity of Fibrimolytic Preparations" IEV. Akad. Nauk. SSSR Ser. Biol., 4 (1977) pp. 602-605.
von Kaulla, "In Vitro Dissolution of Human Clots by Whisky", Lancet 2 (1941) (Nov. 8, 1975) p. 917.
Budzynski Andrei Z.
Olexa Stephanie A.
Sawyer Roy T.
Stent Gunther S.
Rowland Bertram I.
Tarcza John E.
The Regents of the University of California
Wiseman Thomas G.
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