Heme-bearing microparticles for targeted delivery of drugs

Details Heme-bearing microparticles for targeted delivery of drugs Heme-bearing microparticles for targeted delivery of drugs

1994-04-12

1999-04-06

Stanton, Brian R.

Chemistry: molecular biology and microbiology

Treatment of micro-organisms or enzymes with electrical or...

Modification of viruses

435174, 935 22, 935 52, 514 44, A61K 4748, A61K 4800, C12N 1500, C12N 1579

Patent

active

058916890

ABSTRACT:
Methods and compositions are described for the directed delivery of ribozymes or other compounds to specific cells which express the heme receptor on their surface using heme-bearing microparticles. Such microparticles are useful in the directed delivery and accumulation of drugs designed to treat hepatic diseases such as viral hepatitis or hepatoma.

REFERENCES:
patent: 4104466 (1978-08-01), Tsuchida et al.
patent: 4981957 (1991-01-01), Lebleu et al.
patent: 5166320 (1992-11-01), Wu et al.
patent: 5225337 (1993-07-01), Robertson et al.
Majuri et al., 1989. Eur. J. Haematol. 43:220-225, Sep. 1989.
The Merck Index, Tenth Ed., Merck and Co., Inc. 1983, p. 4527.
Aft, R.L., et al., "Hemin-Mediated DNA Strand Scission", J. Biol. Chem., 258(19):12069-12072 (1993).
Cannon, J.B., et al., "Kinetics of the Interaction of Hemin Liposomes with Heme Binding Proteins", Biochemistry, 23(16):3715-3721 (1984).
Carvlin, M.J., et al., "Intercalative and Nonintercalative Binding of Large Cationic Porphyrin Ligands to Calf Thymus DNA", Nucleic Acids Res., 11:6121-6139 (1983).
Chowdhury, N.R., et al., "Fate of DNA Targeted to the Liver by Asialoglycoprotein Receptor-Mediated Endocytosis in Vivo", J. Biol. Chem., 268:11265-11271 (1993).
Clarenc, J.P., et al., "Delivery of Antisense Oligonucleotides by Poly(L-lysine) Conjugation and Liposome Encapsulation", Anti-Cancer Drug Design, 8(1):81-94 (1993).
Felgner, P.L., et al., "Cationic Lipsosome-Mediated Transfection", Nature, 337:387-388 (1989).
Felgner, P.L., "Particulate Systems and Polymers for In Vitro and In Vivo Delivery of Polynucleotides", Advanced Drug Delivery Reviews, 5:163-187 (1990).
Felgner, P.L., et al., "Lipofection: A Highly Efficient, Lipid-Mediated DNA-Transfection Procedure", Proc. Natl. Acad. Sci. USA 84:7413-7417 (1987).
Fuhrhop, et al., In: Porphyrins and Metalloporphyrins, (K.M. Smith, Ed.) (Elsevier, Amsterdam, 804-807 (1975).
Galbraith, R.A., "Heme Binding to Hep G2 Human Hepatoma Cells", J. Hepatol., 10(1):305-310 (1990).
Galbraith, R.A., et al., "Heme Binding to Murine Erythroleukemia Cells", J. Biol. Chem., 260(22):12198-12202 (1985).
Kim, S., et al., "Preparation of Multivesicular Liposomes", Biochimica et Biophysica Acta, 728:339-348 (1983).
Larock, "Comprehensive Organic Transformations", VCH, New York, 966-972 (1989).
Lee, K-D., et al., "Recognition of Liposomes by Cells: In Vitro Binding and Endocytosis Mediated by Specific Lipid Headgroups and Surface Charge Density", Biochimica et Biophysica Acta, 1103:185-197 (1992).
Leonetti, J-P, et al., "Antibody-targeted Liposomes Containing Oligodeoxyribonucleotides Complementary to Viral RNA Selectively Inhibit Viral Replication", Proc. Natl. Acad. Sci. USA, 87(7):2448-2451 (1990).
Leserman, L., et al., "Targeted Liposomes and Intracellular Delivery of Macromolecules", Horizons in Membrane Biotechnology, 95-102 (1990).
Liu, D., et al., "Role of Liposome Size and RES Blockade in Controlling Biodistribution and Tumor Uptake of GM.sub.1 -containing Liposomes", Biochimica et Biophysica Acta, 1104(1):95-101 (1992).
Machy, P., et al., "Interferon Sensitive and Insensitive MHC Variants of a Murine Thymoma Differentially Resistant to Methotrexate-Containing Antibody-Directed Liposomes and Immunotoxin", J. Immunology, 136(8):3110-3115 (1986).
Machy, P., et al., "Elimination or Rescue of Cells in Culture by Specifically Targeted Liposomes Containing Methotrexate or Formyl-Tetrahydrofolate", EMBO Journal, 3(7):1971-1977 (1984).
Milhaud, P.G., et al., "Antibody Targeted Liposomes Containing Poly(rl).cndot.poly(rC) Exert a Specific Antiviral and Toxic Effect on Cells Primed with Interferons .alpha./.beta. or Y", Biochimica et Biophysica Acta, 987:15-20 (1989).
Milhaud, P.G., et al., "Free and Liposome-Encapsulated Double-Stranded RNAs as Inducers of Interferon, Interleukin-6, and Cellular Toxicity", J. of Interferon Res., 11(1):261-265 (1991).
Noe, C., et al., "Inhibition of Cell Proliferation with Antibody-Targeted Liposomes Containing Methotrexate-Y-Dimyristoylphosphatidylethanolamine", Biochimica et Biophysica Acta, 946:253-260 (1988).
R.R.C. New (ed.) "Liposomes: A Practical Approach", IRL Press, Oxford, 179-180 (1992).
Sells, M.A., et al., "Production of Hepatitis B Virus Particles in Hep G2 Cells Transfected with Cloned Hepatitis B Virus DNA", Proc. Natl. Acad. Sci. USA, 84:1005-1009 (1987).
Sinclair, P.R., et al., "Effect of Serum Proteins on Haem Uptake and Metabolism in Primary Cultures of Liver Cells", Biochem. J., 256(19):159-165 (1988).
Smith, A., et al., "Hemopexin-Mediated Heme Uptake by Liver", J. Biol. Chem., 259:12049-12053 (1984).
Suzuki, H., et al., "CD4 and CD7 Molecules as Targets for Drug Delivery from Antibody Bearing Liposomes", Exp. Cell Res., 193(1):112-119 (1991).
Symons, R.H., "Ribozymes", Critical Reviews in Plant Sciences, 10(3):189-234 (1991).
Thierry, A.R., et al., "Multidrug Resistance in Chinese Hamster Cells: Effect of Liposome-Encapsulated Doxorubicin", Cancer Communications, 1(5):311-316 (1989).
Thierry, A.R., et al., "Overcoming Multidrug Resistance in Human Tumor Cells Using Free and Liposomally Encapsulated Antisense Oligodeoxynucleotides", Biochem. Biophys. Res. Comm., 190(3):952-960 (1993).
Thierry, A.R., et al., "Intracellular Availability of Unmodified, Phosphorothioated and Liposomally Encapsulated Oligodeoxynucleotides for Antisense Activity", Nuc. Ac. Res., 20(21):5691-5698 (1992).
Tipping, E., et al., "Interactions of Small Molecules with Phospholipid Bilayers", Biochem. J., 180:327-337 (1979).
Truneh, A., et al., "A Calmodulin Antagonist Increases the Apparent Rate of Endocytosis of Liposomes Bound to MHC Molecules Via Monoclonal Antibodies", Exp. Cell Res., 155:50-63 (1984).
Wang, C.Y., et al., "Highly Efficient DNA Delivery Mediated by pH-Sensitive Immunoliposomes", Biochem., 28:9508-9514 (1989).
Cannon, "Pharmaceutics and Drug Delivery Aspects of Heme and Porphyrin Therapy", J. of Pharm. Sci. 83:435-446 (1993).
Pispisa, et al., "Photophysical Behavior of Poly(L-Lysine) Carrying Porphyrin and Naphthyl Chromophores," Biopolymers 34:435-442 (1994).
Spaltro, "The Synthesis and Characterization of the Manganese (III) Chloride Protoporphyrin IX-Poly (Alpha-Amino Acid) Conjugates," Dissertation Abstracts International 49-07:2678 (1988).
Tsuchida, et al., "Cooperative Reactions of Poly-L-Lysine-Heme Complex with Molecular Oxygen, Carbon Monoxide, or Cyanide Ion," Biochim. et Biophysica Acta 427:520-529 (1976).
Ushakova, et al., "Preparation of Liposomal Forms of Hemin Hydrophobic Derivatives", Bioorg. Khim., 15:1128-1132 (1989).
Yamagishi, et al., "Electric Dichroism Studies on Ferriheme-and Ferroheme-Poly(L-lysine) Complexes at pH 9-12," Biopolymers 21:89-100 (1982).

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