Hematopoietic stem cells and methods of treatment of...

Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Primate cell – per se

Reexamination Certificate

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C435S325000

Reexamination Certificate

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07838290

ABSTRACT:
Isolated, mammalian, adult bone marrow-derived, lineage negative hematopoietic stem cell populations (Lin−HSCs) contain endothelial progenitor cells (EPCs) capable of rescuing retinal blood vessels and neuronal networks in the eye. Preferably at least about 20% of the cells in the isolated Lin−HSCs express the cell surface antigen CD31 and not more than about 1 percent of the cells express Tie-2. The isolated Lin−HSC populations are useful for treatment of ocular vascular diseases.

REFERENCES:
patent: 5843633 (1998-12-01), Yin et al.
patent: 6767737 (2004-07-01), Wilson et al.
patent: 2003/0180265 (2003-09-01), Scott et al.
patent: 2005/0026220 (2005-02-01), Rafii et al.

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