Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Primate cell – per se
Reexamination Certificate
2011-04-05
2011-04-05
Kim, Taeyoon (Department: 1651)
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
Primate cell, per se
C435S370000, C435S325000
Reexamination Certificate
active
07919316
ABSTRACT:
The present invention relates to methods of identifying, collecting and isolating hematopoietic stem cells (HSCs) and compositions of purified HSCs. Specifically, the present invention provides methods of isolating and purifying CD150+HSCs, CD48−HSCs, and CD244−HSCs. The present invention also relates to purified cell samples with enriched CD150+HSCs, CD48−HSCs, and CD244−HSCs populations, as well as methods of treating subjects with such compositions.
REFERENCES:
patent: 5061620 (1991-10-01), Tsukamoto
patent: 5646001 (1997-07-01), Terstappen
patent: 5840502 (1998-11-01), Van Vlasselaer
patent: 6353150 (2002-03-01), Dick
patent: 6-269293 (1994-09-01), None
patent: 10-94390 (1998-04-01), None
patent: 10-136978 (1998-05-01), None
patent: WO 98/21313 (1998-05-01), None
patent: WO/00/14203 (2000-03-01), None
Natori et al. 2000 Method for Preparing a Cell Fraction Containing Hematopoietic Stem Cells. English Translation (human) for WO/2000/14203. p. 1-32.
Adult Stem Cells. 2002. Stem Cells and Future of Regenerative Medicine. Chapter Two. p. 19.
Kiel et al. 2005. SLAM Family Receptors Distinguish Hematopoietic Stem and Progenitor Cells and Reveal Endothelial Niches for Stem Cells. Cell. 121:1109-1121.
Morrison S.J. et al. The biology of hematopoietic stem cells. Annu Rev Cell Dev Biol. 1995;11:35-71.
Domen et al. Self-renewal, differentiation or death: regulation and manipulation of hematopoietic stem cell fate. Mol Med Today. May 1999;5(5):201-8.
Uchida & Weissman. Searching for hematopoietic stem cells: evidence that Thy-1.110 Lin-Sca-1 + cells are the only stem cells in C57BUKa-Thy-1.1 bone marrow. J Exp Med. Jan. 1, 1992;175(1 ):175-84.
Morrison & Weissman. The long-term repopulating subset of hematopoietic stem cells is deterministic and isolatable by phenotype. Immunity. Nov. 1994;1(8):661-73.
Morrison et al. Identification of a lineage of multipotent hematopoietic progenitors. Development. May 1997;124(1 0):1 929-39.
Wagers et al. Little evidence for developmental plasticity of adult hematopoietic stem cells. Science. Sep. 27, 2002;297(5590):2256-9.
Osawa et al. Long-term lymphohematopoietic reconstitution by a single CD34-low
egative hematopoietic stem cell. Science. Jul. 12, 1996;273(5272):242-5.
Wang et al. CD150 is a member of a family of genes that encode glycoproteins on the surface of hematopoietic cells. Immunogenetics. Jul. 2001;53(5):382-94.
Howie et al. Molecular dissection of the signaling and costimulatory functions of CD150 (SLAM): CD150/SAP binding and CD150-mediated costimulation. Blood. Feb. 1, 2002;99(3):957-65.
Howie et al. The role of SAP in murine CD150 (SLAM)-mediated T-cell proliferation and interferon gamma production. Blood. Oct. 15, 2002;100(8):2899-907.
Castro et al. Molecular and functional characterization of mouse signaling lymphocytic activation molecule (SLAM): differential expression and responsiveness in Th1 and Th2 cells. J Immunol. Dec. 1, 1999;163(11):5660-70.
Sidorenko et al. The dual-function CD150 receptor subfamily: the viral attraction. Nat Immunol. Jan. 2003;4(1):19-24.
Yanagi et al. Measles virus receptor SLAM (CD150). Virology. Aug. 1, 2002;299(2):155-61.
Chan et al. SAP couples Fyn to SLAM immune receptors. Nat Cell Biol. Feb. 2003;5(2): 155-60.
Morra et al. Characterization of SH2D1A missense mutations identified in X-linked lymphoproliferative disease patients. J Bioi Chem. Sep. 28, 2001;276(39):36809.
Wiesmann et al. Expression of C027 on murine hematopoietic stem and progenitor cells. Immunity. Feb. 2000;12 (2):193-9.
Christensen et al. Flk-2 is a marker in hematopoietic stem cell differentiation: a simple method to isolate long-term stem cells. Proc Natl Acad Sci USA. Dec. 4, 2001;98(25):14541-6.
Schneider-Schaulies et al. Measles virus induced immunosuppression: targets and effector mechanisms. Curr Mol Med. May 2001; 1(2): 163-81.
Morra et al. X-linked lymphoproliferative disease: a progressive immunodeficiency. Annu Rev Immunol. 2001 ;19:657-82.
Nelson et al. X-linked lymphoproliferative syndrome. Clin Exp Immunol. Dec. 2000;122(3):291-5.
Ando, K. Human CD34− hematopoietic stem cells: basic features and clinical relevance. Int J Hematol. May 2002;75 (4):370-5.
Bhatia et al. A newly discovered class of human hematopoietic cells with SCID-repopulating activity. Nat Med. Sep. 1998;4(9):1038-45.
Donnelly et al. Hematopoietic stem cells can be CD34+ or CD34−. Leuk Lymphoma. Jan. 2001;40(3-4):221-34.
Engelhardt et al. CD34(+) or CD34(−): which is the more primitive? Leukemia. Sep. 2002;16(9):1603-8.
Guo et al. CD34− hematopoietic stem cells: current concepts and controversies. Stem Cells. 2003;21 (1): 15-20.
Nakauchi, H. Hematopoietic stem cells: are they CD34-positive or CD34- negative? Nat Med. Sep. 1998;4 (9):1009-10.
Ogawa M. Changing phenotypes of hematopoietic stem cells. Exp Hematol. Jan. 2002;30(1 ):3-6.
Iwashita et al. Hirschsprung disease is linked to defects in neural crest stem cell function. Science 2003; 301 :972.
Romero et al. Differential expression of SAP and EAT-2-binding leukocyte cell-surface molecules CD84, CD150 (SLAM), CD229 (Ly9) and CD244 (284), Tissue Antigens 2004; 64, No. 2, 132-144.
Osawa et al. In vivo self-renewal of c-Kit+ Sca-1 + Limlow/− hemopoietic stem cells, J. Immunol. (1996), vol. 156, No. 9, pp. 3207-3214.
Christensen et al. F1 k-2 is a marker in hematopoietic stem cell differentiation: A simple method to isolate long-term stem cells. Proceedings of the National Academy of Sciences of the United States of America 2001; 98 No. 25, 14541-14546.
Iwashita Toshihide
Kiel Mark J.
Morrison Sean
Yilmaz Omer H.
Casimir Jones S.C.
Kim Taeyoon
The Regents of the University of Michigan
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