Hematopoietic restricted tyrosine kinase (BPK)

Details Hematopoietic restricted tyrosine kinase (BPK) Hematopoietic restricted tyrosine kinase (BPK)

1995-02-21

1996-08-27

Wax, Robert A.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

435194, 4351723, 435 6, 4352523, 4353201, 435 691, 536 231, 536 232, 935 14, 935 27, 935 56, 935 66, 935 70, 935 72, C12N 121, C12N 510, C12N 1554, C12N 912

Patent

active

055500544

ABSTRACT:
Novel hematopoietic-restricted tyrosine kinases are provided, where the tyrosine kinases provide for autophosphorylation and transphosphorylation. Modulation of the activity of the subject compositions can be used to restrict growth and differentiation, to correct genetic deficiencies, and to elucidate the activation pathway involved with the subject tyrosine kinases. In addition, the tyrosine kinases may be used in a variety of assays as a label or in the production of the phosphorylated peptides.

REFERENCES:
D. Vetrie et al. Nature 361: 226-233 (Jan. 1993).
R. C. Allen et al. Hum. Mol. Genet. 1(3) 216 (1992).
Y. Yamanashi et al. Proc. Natl. Acad. Sci. 86: 6538-6542 (Sep. 1989).
I. P. Wicks et al. Proc. Natl. Acad. Sci. 89: 1611-1615 (Mar. 1992).
D. Kitamura et al. Nuc. Acids Res. 17(22) 9367-9379 (Nov. 1989).
S. M. Dymecki et al. Science 247: 332-336 (Jan. 1990).
D. A. Holtzman et al. Proc. Natl. Acad. Sci. 84: 8325-8329 (Dec. 1987).

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