Hematopoietic cytokine receptor

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Phosphoproteins – e.g. – phosvitin – vitellogenin – etc.

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Details

530350, 5303871, 5303911, 435193, A61K 3816

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active

059257350

ABSTRACT:
Novel receptor polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed. The polypeptides comprise an extracellular ligand-binding domain of a cell-surface receptor that is expressed at high levels in lymphoid tissue, including B-cells and T-cells. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo.

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Genethon, Genexpress; The Genexpress cDNA program, 1995.
Hibi et al., Cell 63: 1149-1157, 1990.
Hochuli et al., Bio/Technology: 1321-1325, Nov., 1988.
Broudy et al., Blood 75(8): 1622-1626, 1990.

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