Hematopoietic cell specific transcriptional regulatory elements

Details Hematopoietic cell specific transcriptional regulatory elements Hematopoietic cell specific transcriptional regulatory elements

1992-07-02

1994-08-23

Wax, Robert A.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

4352402, 4352523, 4353201, 4351723, 536 241, 935 34, 935 36, 935 71, C12N 510, C12N 516, C12N 100, C12N 1563

Patent

active

053407393

ABSTRACT:
A negative transcription regulatory element (a constitutive suppressor) between residues -250 and -190 of the 5' flanking region of the mouse serglycin gene, a positive (hematopoietic cell enhancer) regulatory element located between residues -118 and -81, an equivalent of the TATA- box and a novel eukaryotic promoter that utilizes such equivalent, vectors containing such elements and hosts transformed therewith, are described. These regulatory elements, vectors and hosts are useful in gene transcription of heterologous genes in eukaryotic cells, and especially in hematopoietic cells. In addition, transcriptional factors that bind to these elements are described.

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