Hematopoietic cell composition for use in transplantation

Details Hematopoietic cell composition for use in transplantation Hematopoietic cell composition for use in transplantation

2006-09-05

2006-09-05

Wehbe′, Anne Marie S. (Department: 1633)

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Method of regulating cell metabolism or physiology

C435S373000, C435S383000, C435S325000, C424S093100, C424S093200, C530S350000

Reexamination Certificate

active

07101708

ABSTRACT:
Cell compositions consisting essentially of mammalian hematopoietic CXCR4+stem and progenitor capable to migrate in response to stromal-derived factor 1 (SDF-1) and/or capable to adhere to stromal cells in response to an adhesion-inducing agent, are provided for clinical transplantation. Hematopoietic CXCR4−/lowstem and progenitor cells can be converted into CXCR4+cells by stimulation with a suitable agent. The composition consists preferably of human CD38−/lowCXCR44cells.

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