Hematology control compositions for three populations of leukocy

Details Hematology control compositions for three populations of leukocy Hematology control compositions for three populations of leukocy

1990-04-17

1995-01-10

Housel, James C.

Chemistry: analytical and immunological testing

Composition for standardization, calibration, simulation,...

Particle count or volume standard or control

436 15, 436 16, 436 17, 436 18, 435 2, G01N 1900

Patent

active

053806646

ABSTRACT:
This invention primarily is directed to a hematology reference control solution, the three separate white cell control portions thereof consisting of three types of fixed red cells of determined size distribution for checking the operation of a particle analyzing instrument, including its predetermined lower and upper threshold settings for each class or subclass of leukocytes.
For preparing a human granulocyte analogue, nurse shark erythrocytes are altered and fixed in a chilled solution to simulate in number, size and distribution the granulocytes in human whole blood.
Such a granulocyte analogue is useful as a free-standing reference control, for determination of human granulocytes only, or can be comingled with reference controls for lymphocytes and mononuclear cells for use with multi-parameter instruments to give a trimodal leukocyte reference control, which itself can be included in a multiple-analysis hematology reference control, having components for also determining red blood cell and platelet parameters.

REFERENCES:
patent: 3574137 (1971-04-01), Decasperis
patent: 3873467 (1975-03-01), Hunt
patent: 3973913 (1976-08-01), Louderback
patent: 4250051 (1981-02-01), Armstrong
patent: 4264470 (1981-04-01), Chestain et al.
patent: 4405719 (1983-09-01), Crews et al.
patent: 4485175 (1984-11-01), Ledis et al.
patent: 4575490 (1986-03-01), Ornstein et al.

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