Chemistry: analytical and immunological testing – Composition for standardization – calibration – simulation,... – Particle count or volume standard or control
Patent
1993-06-23
1994-06-14
Housel, James C.
Chemistry: analytical and immunological testing
Composition for standardization, calibration, simulation,...
Particle count or volume standard or control
436 11, 436 15, 436 16, 436 17, 436 18, G01N 3100
Patent
active
053209648
ABSTRACT:
A hematology control product comprising leukocyte analogs is described. The analogs comprise red blood cells which simulate at least two physical properties of human leukocytes. A method for making leukocyte analogs from blood cells having desired physical properties is also described. The process comprises expanding the cell volume, changing the hemoglobin content of the cell and fixing the cell. Generally, the monocyte and lymphocyte analogs leak hemoglobin from the cell while the eosinophil analog has the hemoglobin precipitated in the cell. A further method is described to use the control product to determine whether an automatic instrument is operating within manufacturer's specification.
REFERENCES:
patent: 2656508 (1953-10-01), Coulter
patent: 3502974 (1970-03-01), Coulter et al.
patent: 3741875 (1973-06-01), Ansley et al.
patent: 3836849 (1974-09-01), Coulter et al.
patent: 3873467 (1975-03-01), Hunt
patent: 4219440 (1980-08-01), Runck et al.
patent: 4299726 (1981-11-01), Crew et al.
patent: 4324686 (1982-04-01), Mindschenk
patent: 4358394 (1982-11-01), Crews et al.
patent: 4436821 (1984-03-01), Ryan
patent: 4485175 (1984-11-01), Ledis et al.
patent: 4579824 (1986-04-01), Louderback et al.
patent: 4704364 (1987-11-01), Canver et al.
patent: 4745074 (1988-05-01), Scheier et al.
patent: 4751179 (1988-06-01), Ledis et al.
patent: 4777139 (1988-10-01), Wong et al.
patent: 5008201 (1991-04-01), Ryan
Ojciusi et al., "Characterization of the Inhibitors Effect of Lysolipids on Perforin-Mediated Hemolysis", Mol. Immunology, 27 (3) 257-261, 1990.
Konakanaj et al., "Influence of hypercholesterolemia on morphological and reological charactersitics of . . . ", Atherosclerosis, 76, 209-218, 1989.
Tatsumi, "Alterations of Saponin Hemolysis during Storage of ACD Blood", Vox. Song. 41: 18-24, 1981.
Komber et al., "Alterations in the Activities of Rabbit Erythrocyte Membrane-Bound Enzymes Induced by . . . ", Z. Naturforch, 41C 301-309 1986.
Yeagle, "Cholesterol and the cell membrane", Biochimica et Biophysica Acta, 822, 267-287, 1985.
Davis et al., "Regulation of Cholesterol Synthesis and the potential for its pharmacologic manipulation", Pharmac. Ther., 43, 221-263, 1989.
Shinitzky, Febs Letters, 85, No. 2, 317-320, 1978, "An efficient method for modulation of cholesterol level in cell membrane".
Schroeder, "Membrane Cholesterol Dynamics: Cholesterol Domains and Kinetic Pools", Soc. of Experimental Biol. & Med., 196, 235-252, 1991.
Elliott Michael N.
Fischer Timothy J.
Naylor Nancy R.
Young Carole
Alter Mitchell E.
Cano Milton I.
Coulter Corporation
Housel James C.
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