Chemistry: analytical and immunological testing – Composition for standardization – calibration – simulation,... – Particle count or volume standard or control
Patent
1994-11-21
1996-04-30
Bhat, N.
Chemistry: analytical and immunological testing
Composition for standardization, calibration, simulation,...
Particle count or volume standard or control
436 11, 436 15, 436 16, 436 17, 436 18, G01N 1900
Patent
active
055124852
ABSTRACT:
A hematology control product comprising leukocyte analogs is described. The analogs comprise red blood cells which simulate at least two physical properties of human leukocytes. A method for making leukocyte analogs from blood cells having desired physical properties is also described. The process comprises expanding the cell volume, changing the hemoglobin content of the cell and fixing the cell. Generally, the monocyte and lymphocyte analogs leak hemoglobin from the cell while the eosinophil analog has the hemoglobin precipitated in the cell. A further method is described to use the control product to determine whether an automatic instrument is operating within manufacturer's specification.
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Elliott Michael N.
Fischer Timothy J.
Naylor Nancy R.
Young Carole
Alter Mitchell E.
Bhat N.
Coulter Corporation
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