Helper virus-free herpesvirus vector packaging system

Details Helper virus-free herpesvirus vector packaging system Helper virus-free herpesvirus vector packaging system

1995-07-26

1998-12-22

Elliott, George C.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

435 691, 4351721, 4351723, 4353201, C12N 500, C12N 1500, C12P 2100

Patent

active

058518266

ABSTRACT:
We have now discovered a helper virus free herpesvirus packaging system. This system can be used to package a wide range of desired nucleotide segments, preferably a DNA segment, into an empty herpesvirus particle because of the large genomes of herpesviruses. Preferably, the herpesvirus is an alpha herpesvirus. More preferably, the herpesvirus is an alpha herpesvirus such as Varicella-Zoster virus, pseudorabies virus, or a herpes simplex virus such as HSV-1 or HSV-2. Another preferred herpesvirus is Epstein-Barr virus.

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