Chemistry: molecular biology and microbiology – Process of mutation – cell fusion – or genetic modification – Introduction of a polynucleotide molecule into or...
Patent
1998-01-21
1999-12-07
Degen, Nancy
Chemistry: molecular biology and microbiology
Process of mutation, cell fusion, or genetic modification
Introduction of a polynucleotide molecule into or...
435 6, 435 691, 435375, 435 5, 4353201, 536 231, C12Q 170, C07H 2104, C12N 1511, C12N 1563
Patent
active
05998208&
ABSTRACT:
We have now discovered a helper virus free herpesvirus packaging system. This system can be used to package a wide range of desired nucleotide segments, preferably a DNA segment, into an empty herpesvirus particle because of the large genomes of herpesviruses. Preferably, the herpesvirus is an alpha herpesvirus. More preferably, the herpesvirus is an alpha herpesvirus such as Varicella-Zoster virus, pseudorabies virus, or a herpes simplex virus such as HSV-1 or HSV-2. Another preferred herpesvirus is Epstein-Barr virus.
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Fraefel Cornel
Geller Alfred I.
Lim Filip
Children's Medical Center Corporation
Degen Nancy
Eisenstein Ronald I.
McGarry Sean
Resnick David S.
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