Chemistry: molecular biology and microbiology – Process of mutation – cell fusion – or genetic modification – Introduction of a polynucleotide molecule into or...
Reexamination Certificate
2005-10-04
2005-10-04
Guzo, David (Department: 1636)
Chemistry: molecular biology and microbiology
Process of mutation, cell fusion, or genetic modification
Introduction of a polynucleotide molecule into or...
C435S320100, C435S455000, C435S456000, C435S235100, C435S325000, C435S366000, C435S369000
Reexamination Certificate
active
06951758
ABSTRACT:
A method for the production of adeno-associated virus stocks and recombinant adeno-associated virus stocks that are substantially free of contaminating helper virus is described. The method utilizes transfection with helper virus vectors to replace the infection with helper virus used in the conventional method.
REFERENCES:
patent: 6040183 (2000-03-01), Ferrari et al.
patent: 6093570 (2000-07-01), Ferrari et al.
patent: 6458587 (2002-10-01), Ferrari et al.
Yakobson et al., J. Virol., 1987, vol. 61, No. 4, pp. 972-981.
Bauer et al., Virology, 1993, vol. 193, pp. 478-482.
Ferrari Forrest K.
Samulski Richard Jude
Xiao Xiao
Guzo David
Jenkins & Wilson & Taylor, P.A.
The University of North Carolina at Chapel Hill
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