Chemistry: molecular biology and microbiology – Vector – per se
Reexamination Certificate
2006-05-16
2006-05-16
Guzo, David (Department: 1636)
Chemistry: molecular biology and microbiology
Vector, per se
C435S235100, C435S455000, C514S04400A, C424S093200
Reexamination Certificate
active
07045347
ABSTRACT:
This invention provides helper-dependent adenovirus cloning vectors and helper adenoviruses, and methods for making and Using such preparations, wherein the helper adenoviruses contain recombinase target sites that are useful in reducing the level of contamination of helper virus in helper-dependent adenovirus vector preparations.
REFERENCES:
patent: 4510245 (1985-04-01), Cousens et al.
patent: 4797368 (1989-01-01), Carter et al.
patent: 4920209 (1990-04-01), Davis et al.
patent: 4920211 (1990-04-01), Tibbetts et al.
patent: 5670488 (1997-09-01), Gregory et al.
patent: 5849553 (1998-12-01), Anderson et al.
patent: 5882877 (1999-03-01), Gregory et al.
patent: 5919676 (1999-07-01), Graham et al.
patent: 6080569 (2000-06-01), Graham et al.
patent: WO 93/19092 (1939-09-01), None
patent: WO 93/06223 (1993-04-01), None
patent: WO 93/19191 (1993-09-01), None
patent: WO 94/08026 (1994-04-01), None
patent: WO94/12649 (1994-06-01), None
patent: WO95/27071 (1995-12-01), None
patent: WO 96/13587 (1996-05-01), None
patent: WO 96/40955 (1996-12-01), None
patent: WO 97/05255 (1997-02-01), None
patent: WO 97/32481 (1997-09-01), None
patent: WO 99/41400 (1999-08-01), None
Basak SK et al. “Modifying Adenoviral Vectors for Use as Gene-Based Cancer Vaccines”, Viral Immun. vol. 17: p. 182-196. 2004.
Dang, CV et al. “Gene Therapy and Translational Cancer Research”, Clin. Cancer Res., vol. 5: p. 471-474, 1999.
Gura T. “Systems for Identifying New Drugs Are Often Faulty”, Science, vol. 278: p. 1041-1042, 1997.
Orkin et al. Report and Recomendations . . . Gene Therapy. NIHPress. Dec. 7, 1995. p. 1-40.
Miller et al. FASEB. vol. 9:190-199, Feb. 1995.
Marshall. Science.369:1050-1055, Aug. 1995.
Culver et al. TIG. 10(5):174-178, May 1994.
Hodgson. Exp Opin Ther. Patents. 5(5):459-468, May 1994.
Neuwett et al Behavioral and Brain Sciences. 18:1-9 (1995).
Wolf Current Opinion in Neurobiology. 3:743-748 (1993).
McGrory et al Virology, 163:614-617 (1988).
Graham et al. Methods in Molecular Biology 7:109-128 (1991).
Kilby et al. Trends Genet. 9 413-421 (1993).
Yang et al. Proc Natl. Acad. Sci. USA 91:4407-4411 (May 1994).
Anton, M., and F. L. Graham, 1995, Site-specific recombination mediated by an adenovirus vector expressing the Cre recombinase protein: a molecular switch for control of gene expression, J. Virol. 69: 4600-4606.
Araki, K., J. Araki, J. I. Miyazaki, and P. Vassali, 1995, Site-specific recombination of a transgene in fertilized eggs by transient expression of Cre recombinase. Proc. Nat'l. Acad. Sci. USA 92: 160-164.
Bett, A. J., L. Prevec, and F. L. Graham, 1993, Packaging capacity and stability of human adenovirus type 5 vectors. J. Virol. 67: 5911-5921.
Bett, A. J., W. Haddara, L. Prev, and F. L. Graham, 1994, An efficient and flexible system for construction of adenivorus vectors with insertions or deletions in early region 1 and 3. Proc. Nat'l. Acad. Sci. USA 91:8802-8806.
Brody, H. A. Jaffe, N. T. Eissa, and C. Danel. 1994. Administration of an adenivorus containing the human CFTR cDNA to the respiratory tract of individuals with cystic fibrosis, Nature Genetics 8: 42-51.
DiSanto, J. P., W. Mueller, D. Guy-Grand, A. Fischer, and K. Rajewsky, 1995, Lymphoid development in mice with a targeted deletion of the interleukin 2 receptor chain, Proc. Nat'l. Acad. Sci. USA 92: 377-381.
Gage, P J., B. Sauer, M. Levin and J. C. Glorioso. 1992 A cell-free recombination system for site-specific integration of multigenic shuttle plasmids into the herpes simplex virus type 1 genome. J. Virol. 66: 5509-5515.
Graham, F. L. and L. Prevec. 1991. Manipulation of adenovirus vectors. In Murray E.J. (ed.), Methods in Molecular Biology The Humana Press Inc Clifton, N.J. vol. 7 (Gene Transfer and Expression Protocols): 109-128.
Graham F. L. and L. Prevec. 1992. Adenovirus-based expression vectors and recombinant vaccines. in: Vaccines. New Approaches in Immunological Problems., ed. Ellis, R.W. Butterworth-Heinemann, Boston, MA: 363-390.
Graham F. L., J. Smiley, W C. Russel and R. Naim. 1977 Characteristics of a human cell line transformed by DNA from human adenovirus type 5., J. Gen. Virol. 36: 59-72.
Gu, H. J. D March, P.C. Orban, H. Mosemann and K Rajewsky 1994. Deletion of a DNA polymerase B gene segment in T cells using cell type-specific gene targeting. Science 265 103-106.
Kilby, N. J., M. R. Snaith, and J. A. H. Murray. 1993. Site-specific recombinases: tools for genome engineering Trends Genet. 9: 413-421.
Metzger, D., J. Clifford, H. Chiba and P. Chambon. 1995. Conditional site-specific recombination in mammalian cells using a ligand-dependent chimeric Cre protein. Proc. Nat'l. Acad. Sci. USA 92: 6991-6995.
Pichel, J. G., Lakso, and H. Westphal. 1993. Timing of SV40 oncogene activation by site-specific recombination determines subsequent tumor progression during murine lens development. Oncogene 8: 3333-3342.
Sauer, B. 1994. Site-specific recombination: developments and applications. Cur. Opin. Biotech. 5: 521-527.
Sauer, Brian and Nancy Henderson. 1988. Site-specific DNA recombination in mammalian cells by the Cre recombinase of bacteriophage Pl. Proc. Nat'l. Acad. Sci. USA 85: 5166-5170nn.
Sauer, B. and N. Henderson. 1989. Cre-stimulated recombination of IoxP-containing DNA sequences placed into the mammalian genome. Nucl. Acids Res. 17: 147-161.
Sauer, B., and N. Henderson. 1990. Targeted insertion of exogenous DNA into the eukaryotic genome by the Cre recombinase. The New Biologist 2: 441-449.
Sauer, B., M. Whealy, A. Robbins and L. Enquist. 1987. Site-specific insertion of DNA into a pseudorabies virus vector. Proc. Nat'l. Adac. Sci. USA 84: 9108-9112.
Smith A. J. H., M. A. DeSousa, B. Kwabi-Addo, A. Heppel-Parton, H. Impey, and P. Rabbits. 1995. A site-directed chromosomal translocation induced in embryonic stem cells by Cre-IoxP recombination. Nature Genetics 9: 376-385.
Rabbits. 1995. A site-directed chromosomal translocation induced in embryonic stem cells by Cre-IoxP recombination. Nature genetics 9: 376-385.
Sternberg, N., B. Sauer, R. Hoess, and K. Abremski. 1986. Bacteriophase P1 cre gene and its regulatory region; Evidence for multiple promotors and for regulation by DNA methylation., J. Mol. Biol. 187: 197-212.
Van Deursen, J., M. Fornerod, B. Van Rees, and G. Grosveld. 1995. Cre-mediated site specific translocation between non-homologous mouse chromosomes. Proc. Nat'l. Acad. Sci. USA 92: 7376-7380.
Mittal, S.K., McDermott, M.R., Johnson, D.C., Prevec, L. and F. L. Graham. 1993. Monitoring foreign gene expression by a human adenovirus-based vector using the firefly luciferase gene as a reporter, Virus Research, 28: 67-90.
Hanke, T., Frank L. Graham, Kenneth L. Rosenthal and David C. Johnson. 1991. Identification of an immunodomimant cytotoxic t-lymphocyte recognition site in glycoprotein B of herpes simplex virus by using recombinant adenovirus vectors and synthetic peptides. 1991. J. of Virology, 65: 1177-1186.
Graham, F.L., 1987. Growth of 293 cells in suspension culture. J. Gen. Virol. 68: 937-940.
Quantin, B., Leslie D. Pericaudet, Shahragim Tajbakhsh and Jean-Louis Mandel. 1992. Adenovirus as an expression vector in muscle cells in vivo. Proc. Nat'l. Acad. Scie. 89: 2581-2584.
Bett, A.J., Wael Haddara, Ludvik Prevec and Frank L. Graham, 1994. Proc. Nat'l. Acad. Sci. 91: 8802-8806.
Rosenfeld, M.A. et al., 1992. In vivo transfer of the human cystic fibrosis transmembrane conductance regulator gene to the airway epithelium, Cell. 68: 143-155.
W. J. McGrory, D. S. Baulista and F. L. Graham. 1998. A simple technique for the resue of early region 1 mutations into infectious human adenovirus type 5, Virology 163: 614-617.
Wang, P., Anton, F. L. Graham and S. Bacchetti. High Frequency recombination between IoxP sites in human chromosomes mediated by an adeniovorus vector expressing Cre recombinase.
Kornberg & Baker (DNA Replication, Chapter 21-6, pp 806-817, W. H. Freeman, NY 2ndEdition, 1992.
Russ, Andreas P., et al., 1996,. Self-deleting Retrovirus Vectors for Gene Terapy, J. of Virology, pp. 4927-4932.
RG Crystal, Science,, “Transfer of
Anton Martina
Graham Frank L.
Rudnicki Michael A.
Advec, Inc.
Beusse Brownlee Wolter Mora & Maire P.A.
Burkhart Michael D.
Fischer, Esq. Joseph
Guzo David
LandOfFree
Helper dependent adenovirus vectors based on integrase... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Helper dependent adenovirus vectors based on integrase..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Helper dependent adenovirus vectors based on integrase... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3568239