Heliothis glutamate receptor

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

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C435S007200, C435S007210, C436S501000

Reexamination Certificate

active

10644639

ABSTRACT:
The present invention is directed to a nucleic acid encoding a lepidopteran glutamate-gated chloride channel. Vectors and host cells comprising the nucleic acid are also provided. A method of identifying agents that modulate the activity of a lepidopteran glutamate-gated chloride channel is also provided. Such agents are useful as insecticides.

REFERENCES:
patent: 5527703 (1996-06-01), Cully et al.
patent: 5693492 (1997-12-01), Cully et al.
patent: WO 98/49185 (1998-11-01), None
patent: WO 99/07828 (1999-02-01), None
Nakanishi, Molecular Diversity of Glutamate Receptors and Implications for Brain Function. Oct. 23, 1992. SCIENCE 258:597-603.
Smith, McHardy M. et al., May 9, 2000,Nodulisporic acid opens insect glutamate-gated chloride channels: Identification of a new high affinity modulator. Biochemistry. (vol. 39, No. 18): pp. 5543-5554.
Delany et al., 1998,Cloning and Localisation of an Avermectin Receptor-Related Subunit from Haemonchus contortus. Mol. Biochem. Parasit. (97): 177-187.
Pomes, A. et al., May 23, 1997,Target Size Analysis of an Avermectin Binding Site from Drosphila melnogaster. Biochimica et Biophysica Acta. Protein Structure and Molecular Enzymology. (vol. 1339, No. 2): 233-238.
Yu, S. J. et al., 1996,InsecticideSsusceptibility and Detoxification Enzyme Activities in Permethrin-selected Diamondback Moths. Pesticide Biochemistry and Physiology. (vol. 56, No. 1): 69-77.
Cully et al., 1996,Identifiction of a Drosophila melanogaster Glutamate-gated Chloride Channel Sensitive to the Antiparasitic Agent Avermectin. J.Biol. Chem. (271): 20187-20191.
Cully et al., 1994,Cloning of an Avermectin-Sensitive Glutamate-Gated Chloride Channel from Caenorhabditis elegans. Nature (371): 707-711.
Mikayama et al., 1993,Molecular Cloning and Functional Expression of a cDNA Encoding Glycosylation-Inhibiting Factor. Proc. Natl. Acad. Sci. USA (90): 10056-10060.
Arena et al., 1992,Expression of a Glutamate-Activated Chloride Current in Xenopus Oocytes Injected with Caenorhabiditis elegans RNA: Evidence for Modulation by Avermectin. Molecular Brain Research (15): 339-348.
Arena et al., 1991,Avermectin-Sensitive Chloride Currents Induced by Caenorhabitis elegans RNA in Xenopus Oocytes. Molecular Pharm. (40): 368-374.
Voet et al., 1990,Biochemistry. John Wiley & Sons, Inc. pp. 126-128; 228-234.

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