Helicobacter system and uses thereof

Details Helicobacter system and uses thereof Helicobacter system and uses thereof

2006-11-10

2011-10-04

Navarro, Albert (Department: 1645)

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

C424S093400

Reexamination Certificate

active

08029777

ABSTRACT:
Helicobacterbased preparations comprising a pharmacologically active molecule of interest are disclosed, as well as methods of preparing and using said preparations. In particular,Helicobacter pylorivectors, vector plasmids and recombinant cells that include a sequence encoding a pharmacologically active molecule of interest useful in therapeutic treatments and/or vaccination against disease are provided. Delivery of the pharamacologically active molecules is provided at the mucosal surface, such as the gastric mucosa or nasal membranes, to provide effective and continuous delivery of a pharmacologically active agent. In some embodiments, theHelicobacterprovides exposure of a desired molecule of interest though the surface of theHelicobacter, providing exposure of the antigen to the host at the gastric mucosa. LiveHelicobacter pylorivaccines are also provided. Vectors and shuttle vector constructs of theHelicobacterare also disclosed.

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