Helicobacter pylori proteins useful for vaccines and diagnostics

Details Helicobacter pylori proteins useful for vaccines and diagnostics Helicobacter pylori proteins useful for vaccines and diagnostics

1995-06-06

2000-07-18

Bui, Phoung T.

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Bacteria or actinomycetales; media therefor

42419711, 4241841, 4241851, 4241901, 4242341, 4242361, 435 912, 435975, 4353201, 435 6, 435 71, 435 691, 435 693, 435 713, 435 914, 435325, 435243, 4352523, 514 44, 530350, 536 231, 536 237, A61K 39106, C07H 2104, C07K 14205, C12N 121

Patent

active

060906111

ABSTRACT:
A cytotoxin associated immunodominant antigen and the nucleic acid encoding the antigen from Helicobacter pylori are described. This antigen was identified from the cytotoxin positive CCUG 17874 Helicobacter pylori strain, and both the antigen and the DNA encoding it have been sequenced. The antigen is a hydrophilic, surface-exposed protein having a molecular weight of 120-132 kDa. The nucleic acid encoding the antigen may be incorporated into a vector for transformation of host cells for expression of the antigen. Both the DNA and the antigen can be used in assays for detection of disease or infection by Helicobacter pylori, and may find use in treating and preventing infection by Helicobacter pylori and the diseases associated with such infection.

REFERENCES:
patent: 4882271 (1989-11-01), Evans et al.
patent: 5292658 (1994-03-01), Cormier et al.
patent: 5354854 (1994-10-01), Bourque et al.
patent: 5403924 (1995-04-01), Cover et al.
Kahn et al. J. Exp. Med. 172(2), 1990, p 589-597.
Orkin et al. Report and Recommendations of the Panel to Assess the NIH Investment in Research on Gene Therapy, Dec. 1995.
Clayton et al. Infection and Immunity, vol. 57, No. 2, Feb. 1989, p 623-629.
HP Worldwide, Feb. 1992, p 1-8.
Pei et al. J Biol Chem 266(25), 1991, p 16363-16369.
Austin et al., "Structural Comparison of Urease and a GroEL Analog from Helicobacter pylori", J. Bacteriol., 1992, 174 (22), 7470-7473.
Apel et al., "Antibody Response of Patients Against a 120 kDa Surface Protein of Campylobacter pylori", Aentralblat fur Bakterio. Microb. Und Hygiene, 1988, 268, 271-276.
Blaser, "Gastric Campylobacter-like Organismb, Gastritis, and Peptic Ulcer Disease", Gastroenterology, 1987, 93, 371-383.
Blaser, "Helicobacter pylori: Its Role in Disease", Clin. Infect. Dis., 1992, 15, 386-391.
Cover et al., "Characterization of and Human Serologic Response to Proteins in Helicobacter pylori Broth Culture Supernatants with Vacuolizing Cytotoxin Activity", Infect. Immun., 1990, 58(3), 603-610.
Cover et al., "Purification and Characterization of the Vacuolating Toxin from Helicobacter pylori", J. Biol. Chem., 1992, 267(15), 10570-10575.
Cover et al., "Serum Neutralizing Antibody Response to the Vacuolating Cytotoxin of Helicobacter pylori", J. Clin. Invest., 1992, 90, 913-918.
Cover et al., "Human serologic response to Campylobacter pylori cytotoxin-associated proteins", Gastroenterology, 1989, 96 (5/2), A101, abstract.
Crabtree et al., "Expression of 120 kilodalton protein and cytotoxicity in Helicobacter pylori", J. Clin. Pathol., 1992, 45, 733-734.
Cussac et al., "Expression of Helicobacter pylori Urease Genes in Escherichia coli Grown under Nitrogen-Limiting Conditions", J. Bacteroil., 1992, 174(8), 2466-2473.
Dooley et al., "Prevalence of Helicobacter Pylori Infection and Histologic Gastritis in Asymptomatic Persons", New Engl. J. Med., 1989, 321, 1562-1566.
Drumm et la., "Intrafamilial Clustering of Helicobacter Pylori Infection", New Engl. J. Med., 1990, 322(6), 359-363.
Dunn et al., "Identification and Purification of a cpn60 Heat Shock Protein Homolog from Helicobacter pylori", Infect. Immun., 1992, 60(5), 1946-1951.
Evans et al., "Urease-Associated Heat Shock Protein of Helicobacter pylori", Infect. Immun., 1992, 60(5), 2125-2127.
Evans et al., "A Sensitive and Specific Serologic Test for Detection of Campylobacter pylori Infection", Gastroenterology, 1989, 96, 1004-1008.
Figura et al., H. Pylori, Gastritis and Peptic Ulcer, Malfrthheiner et al. (eds.), Springer Verlag, Berlin, 1990.
Gerstenecker et al., "Serodiagnosis of Helicobacter pylori Infections with an Enzyme Immunoassay Using the Chromatographically Purified 120 Kilodalton Protein", Eur. J. Clin. Microbiol. Infect. Dis., 1992, 11(7), 595-601.
Goodwin et al., "Transfer of Campylobacter pylori and Campylobacter mustelae to Helicobacter gen. Nov. As Helicobacter pylori comb. Nov. And Helicobacter mustelae comb. Nov., Respectively," Int. J. Syst. Bacteriol., 1989, 39(4), 397-405.
Graham et al., "Epidemiology of Helicobacter pylori in an Asymptomatic Population in the United States", Gastroenterology, 1991, 100, 1495-1501.
Graham et al., "Seroepidemiology of Helicobacter pylori Infection in India: Comparison of Developing and Developed Countries", Digestive Diseases and Sciences, 1991, 36(8), 1084-1088.
Jones et al., "Antibody to the gastric campylobacter-like organism ("Campylobacter pyloridis")--Clinical correlations and distribution in the normal population", Med. Microbiol., 1986, 22, 57-62.
Leunk, "Production of a Cytotoxin by Helicobacter pylori", Rev. Infect. Dis., 1991, 13(8), S686-S689.
Leying et al., "Cloning and genetic characterization of a Helicobacter pylori flagellin gene", Mol. Microbiol., 1992, 6(19), 2863-2874.
Morris et al., "Seroepidemiology of Campylobacter pyloridis", N.Z. Med. J., 1986, 99(809), 657-659.
Parsonnet et al., "Helicobacter Pylori Infection and the Risk of Gastric Carcinoma", New Engl. J. Med., 1991, 325(16), 1127-1131.
Perez-Perez et al., "Characteristics of Helicobacter pylori Variants Selected for Urease Deficiency", J. Infect. Immun., 1992, 60(9), 3658-3663.
Thomas et al., "Isolation of Helicobacter pylori from human faeces", Lancet, 1992, 340, 1194-1195.
Warren et al., "Unidentified Curved Bacilli on Gastric Epithelium in Active Chronic Gastritis", Lancet, 1983, 1273-1275.

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