Helicobacter pylori proteins useful for vaccines and diagnostics

Details Helicobacter pylori proteins useful for vaccines and diagnostics Helicobacter pylori proteins useful for vaccines and diagnostics

1995-06-06

2000-06-20

Stucker, Jeffrey

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

435 6, 435 693, 435 701, 435 711, 435 712, 435 912, 4353201, 530350, 42419711, 4241901, 514 44, 536 237, A61K 3902, C07H 2104, C07K 14205, C12N 120

Patent

active

060777060

ABSTRACT:
Helicobacter pylori known to cause or be a cofactor in type B gastritis, peptic ulcers, and gastric tumors. In both developed and developing countries, a high percentage of people are infected with this bacterium. The present invention relates generally to certain H. pylori proteins, to the genes which express these proteins, and to the use of these proteins for diagnostic and vaccine applications. Specifically, molecular cloning, nucleotide, and amino add sequences for the H. pylori cytotoxin (CT), the "Cytotoxin Associated Immunodominant" (CAI) antigen, and the heat shock protein (hsp60) are described herein.

REFERENCES:
patent: 4882271 (1989-11-01), Evans et al.

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