Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1995-02-23
1996-08-20
Housel, James C.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 771, G01N 3353, C12N 100
Patent
active
055478441
ABSTRACT:
Chemotactin, diethyl phthalate, is shown to be a chemoattractant secreted by H. pylori. Chemotactin attracts phagocytic cells with a resulting inflammatory episode. Chemotactin and its metabolites may be used for diagnosis and monitoring courses of infection by H. pylori or other chemotactin secreting organisms. In addition, chemotactin may be used in research for studying the inflammatory process, for identifying new drugs for modulating chemoattraction and activation of phagocytic cells, and for inducing an inflammatory response as a therapeutic intervention.
REFERENCES:
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Reymunde, et al., Production Of Chemoattractant by Helicobacter pylori (Sep. 1993) Digestive Diseases And Sciences, vol. 38, No. 9, pp. 1697-1701.
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"Kozol, et al., A Neutrophil Chemotactic Factor Present In H. pylori But Absent In H. Mustelae" (Jan. 1993) Digestive Diseases & Sciences, vol. 38, No. 1, pp. 137-141.
J. L. Wallace, Possible Mechanisms and Mediators of Gastritis Associated with Helicobacter pylori Infection (Undated) University of Calgary, Calgary, Alberta, Canada.
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Mai, et al., Surface Proteins From Helicobacter pylori Exhibit Chemotatic Activity For Human Leukocytes and Are Presentin Gastric Mucosa (Feb. 1992) The Journal of Experimental Medicine, vol. 175, pp. 517-525.
Craig, et al., Helicobacter pylori Secretes A Chemotactic Factor For Monocytes And Neutrophils (Nov. 1991) UCLA School of Medicine, Los Angeles, California.
Driven, et al., Determination of Four Metabilites Of The Plasticizer D192--Ethylhexylo Phthalate In Human Urine Samples (1993) Int. Arch Occup Environ Health 64:555-560.
Nielse, et al., Chemotactic Activity of Helicobacter pylori Sonicate For Human Polymorphonuclear Leucocytes and Monocytes (1992) Gut, 33:738-742.
Anton Peter A.
Faull Kym F.
Reeve, Jr. Joseph R.
Walsh John H.
Housel James C.
Portner Ginny Allen
Rowland Bertram I.
The Regents of the University of California
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