Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Reexamination Certificate
2007-09-18
2007-09-18
Navarro, Mark (Department: 1645)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
C424S164100, C530S388700
Reexamination Certificate
active
10761201
ABSTRACT:
A novelHelicobacter pyloriblood group antigen binding (BAB) adhesin protein was isolated and purified, whereby said protein or fractions thereof bind specifically to fucosylated blood group antigens. The protein sequence of said adhesin is disclosed in this application. Simultaneously the DNA sequences for two genes, babA and babB, producing highly similar proteins, are disclosed. Said adhesin and/or DNA is useful for diagnose and therapy and/or prophylaxis directed againstH. pyloriinduced infections, e.g. gastritis and acid peptic disease, i.e. active vaccination.A new immunoglobulin composition, which exhibits specific activity to a Lewisbantigen bindingHelicobacter pyloriadhesin, or preferably, monoclonal and/or polyclonal antibodies to said adhesin offer a new and more efficient method of treatment and/or prevention of gastrointestinal diseases, caused byHelicobacter pylorior otherHelicobacterspecies, i.e. passive vaccination.
REFERENCES:
patent: 4444879 (1984-04-01), Foster et al.
patent: 5258177 (1993-11-01), Uemura et al.
patent: 5262156 (1993-11-01), Alemohammad
patent: 5538729 (1996-07-01), Czinn et al.
patent: 5625124 (1997-04-01), Falk et al.
patent: 5837502 (1998-11-01), Smith
patent: 5846751 (1998-12-01), Pronovost et al.
patent: 5883079 (1999-03-01), Zopf et al.
patent: 5897475 (1999-04-01), Pace et al.
patent: 6051416 (2000-04-01), Pace et al.
patent: 6410719 (2002-06-01), Boren et al.
patent: 6576244 (2003-06-01), Weltzin et al.
patent: 6709656 (2004-03-01), Boren et al.
patent: 2004/0265427 (2004-12-01), Boren
patent: 2005/0009037 (2005-01-01), Chang et al.
patent: 2724936 (1994-09-01), None
patent: WO92/01718 (1992-02-01), None
patent: WO97/12908 (1995-04-01), None
Amara, A et al (1995), Feb. 13, Voo. 185(3) Neuroscience letters (Ireland), pp. 147-150, Molecular detection of methionine in rat brain using specific antibodies, abstract only.
Aucher, Pe tal, J. Clinical Microbiology, vol. 36(6), pp. 931-936, Apr. 1998.
Bai, Y et al., World. J. Gastroenterology, vol. 10(17), pp. 2560-2562, 2004, Cloning and expression and immunogenicity of Helicobacter pylori BabA2 gene.
Bina, J et al, Journal of Bacteriology, May 2000, vol. 182(9), pp. 2370-2375, Functional expression inEscherichia coliand membrane topology of porin HopE, a member of a large family of conserved proteins inHelicobacter pylori.
Boren and Falk, 1995,Helicboacter pyloribinds to blood group antigens. Scientific American Science and Medicine, Sep./Oct. pp. 28-37.
Cover, Timothy L, Crisp abstract, identification No: 5R01DK053623-07,H. pyloryfactors associated with peptic ulcer disease (abstract only).
Doig, P et al, Journal of Bacteriology, Oct. 1995, vol. 177(19), pp. 5447-5452, Isolation and Characterization of a conserved porin protein fromHelicobacter pylori.
Durrant, LG et al, Hybridoma, vol. 12(6), 1993, Development of Second generation Monoclonal antibodies recognizing LewisY/B antigen by Anti-idiotypic immunization.
Exner, M.M et al, Infection and Immunity, vol. 63(4), pp. 1567-1572, Apr. 1995, Isolation and Characterization of a Family of Porin Proteins fromHelicobacter pylori.
Hennig, E.E. et al, Infection and Immunity, Jun. 2004, vol. 72(6), pp. 3429-3435, Heterogeneity amongHelicobacter pyloristrains in expression of the outer membrane protein BabA.
Pride, David T. et al, Infection and Immunity, vol. 69(3), pp. 1160-1171, Feb. 2001, Allelic Variation withinHelicobacter pyloribabA and babB.
Durrannt et al (1993), reference of record.
Essery et al (1994), FEMS Immunology Medical Microbiology, Jun. , vol. 9(1), pp. 15-21, Detection of microbial surface antigens that bind Lewis(a) antigen.
Bina et al , reference of record.
Cover Crisp Document reference of record.
Pride et al (2001) reference of record.
Boren et al (1995) reference of record.
Boren et al (1995, reference of record).
Durrant et al (1993, reference of record).
Huang, J et al (1992), Journal of General Microbiologi, vol. 138, pp. 1503-1513, Identification of erythrocyte-binding antigens inHelicobacter pylori.
Aspholm-Hurtig et al, Science, vol. 305, Jul. 23, 2004, pp. 5619-522.
Hennig, Ewa E. et al, Infection and Immunity, Jun. 2004, pp. 3429-3435, vol. 72(6), Heterogeneity amongHelicobacter pyloristrain in Experssion of the outer membrane protein BabA.
Pride, David T et al, Infection and Immunity, Feb. 2001, pp. 1160-1171, vol. 69(2), Allelic Variation withinHelicobacter pyloribabA and babB.
Henning, Ewa E et al, Infection and Immunity, vol. 74(5), pp. 3046-3051, May 2006, Multiple Chromosomal Loci for the babA Gene inHelicobacter pylori.
Solnick, Jay V e tal, PNAS, Feb. 17, 2004, vol. 101(7), pp. 2106-2111, Modification ofHelicobacter pyloriouter membrane protein expression during Experimental infection of rehesus macaques.□□
Boren et al., Science, vol. 262, p. 1892, (Dec. 1993).
Alkout et al., Dialog Information Services, File 34, Scisearch, Dialog accession No. 15596361, Gastroenterology, vol. 112, No. 4, pp. 1179-1187, (1997).
Clyne et al., Dialog Information Services, File 34, Scisearch, Dialog accession No. 15313697, FEMS Immunology and Medical Microbiology, vol. 16, No. 2, pp. 141-155, (1996).
Chan et al., Gycobiology, vol. 5, No. 7, pp. 683-688, (1995).
Alkout et al., Gut, vol. 37, (Suppl. 7), p. A21, Abstract 84, (Jul. 1995).
Ho et al., European Journal of Gastroenterology and Hepatology, vol. 7, pp. 121-124, (1995).
Huang et al., Journal of General Microbiology, vol. 138, pp. 1503-1513, (1992).
McKibbin et al., The Journal of Biological Chemistry, vol. 257, No. 2, pp. 755-760, (Jan. 1982).
Oriol, Transplantation proceedings, vol. 19, No. 6, pp. 4416-4420, (Dec. 1987).
Smith, Australian Vet. Pract., vol. 26, No. 3, pp. 140-145, (Sep. 1996).
Chmiela et al., FEMS Immunology and Medical Microbiology, vol. 10, Nos. 3-4, pp. 307-326, (Feb. 1995).
Lelwala-Guruge et al., FEMS Immunology and Medical Microbiology, vol. 11, No. 1, pp. 73-77, (Mar. 1995).
Jiang et al., Molecular Microbiology, vol. 20, No. 4, pp. 833-842.
Exner et al., Infection and Immunity, vol. 63, No. 4, pp. 1567-1572, (Apr. 1995).
Doig et al., Journal of Bacteriology, vol. 177, No. 19, pp. 5447-5452, (Oct. 1995).
Hirmo et al., Glycoconj . J., vol. 13, No. 6, pp. 1005-1011, (Dec. 1996).
Huang et al., Journal of General Microbiology, vol. 138, pp. 1503-1513, (1992).
Cameron et al., Dialog Information Services, File 34, Scisearch, Dialog accession No. 14645778, Infection and Immunity, vol. 64, No. 3, pp. 891-896, Mar. 1996.
Farokhnia, Antibody specific for a plasmid encoded protein ofHelicobacter pylori, A Thesis for the degree of master of Science in the graduate School of the Texas Woman's University, (Dec. 1995).
Amano, Akita J. Med., vol. 24, pp. 100-108, English translation, (1997).
Sjostedt et al., Ann. Surg., vol. 207, No. 3, pp. 341-346, abstract, (Mar. 1998).
Blakely et al., J. Med. Microbiol., vol. 15, No. 4, pp. 519-529, abstract, (Nov. 1982).
Huang et al., FEMS Microbiology Letters, vol. 56, No. 1, pp. 109-112, (1988).
Newell, Journal of General Microbiology, vol. 133, pp. 163-170.
Essery et al., FEMS Immunology Med. Microiol., vol. 91, No. 1, pp. 15-21, (Jun. 1994).
Lelwala-Guruge et al., Zbl. Bakt, vol. 280, pp. 93-106, (1993).
Falk et al., Proc. Natl. Acad. Sci., vol. 90, pp. 2035-2039, (Mar. 1993).
Boren et al., Trends in Microbiology, vol. 2, No. 7, pp. 221-228, (Jul. 1994).
Smith et al., The Lancet, vol. 343, No. 8896, pp. 543, abstract, (Feb. 1994).
Fauchere et al., Microbial Pathogenesis, vol. 9, pp. 427-439, (1990).
Enders et al., Infection Immunity, vol. 63, No. 7, pp. 2473-2477, (Jul. 1995).
Moran, FEMS Immunology and Medical Microbiology, vol. 10, pp. 271-280, (1995).
Lingwood et al., Lancet, vol. 2, No. 8657, pp. 238-241, (Jul. 1989).
Thomas Boren et al., “Attachment ofHelicobacter pylori. . . ,” Science, Dec. 17, 1993, vol. 262, pp. 1892-1895.
Mark A. Agius et al., “Monoclonal anti-idiotypic antibodies against . . . ,” The Journal of Immunology, Jan. 1, 1988, vol. 140, No. 1, pp. 62-68.
Arnqvist Anna
Boren Thomas
Hammarstrom Lennart
Ilver Dag
Normark Staffan
Birch & Stewart Kolasch & Birch, LLP
Navarro Mark
Portner Ginny Allen
LandOfFree
Helicobacter pylori adhesin binding group antigen does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Helicobacter pylori adhesin binding group antigen, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Helicobacter pylori adhesin binding group antigen will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3733613