Hedgehog protein

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues

Reexamination Certificate

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C536S023500, C536S023510

Reexamination Certificate

active

07015308

ABSTRACT:
Disclosed are a novel hedgehog protein, i.e., a Desert hedgehog protein of human origin including mature and precursor forms, a DNA encoding the protein, a monoclonal antibody recognizing the protein, a process for producing the protein, and a method for detecting the protein. The hedgehog protein is useful in establishment of hybridomas which produce antibodies recognizing the protein, and the monoclonal antibody is useful in detection and purification of the protein. The hedgehog protein, DNA, and monoclonal antibody of this invention have efficacy in elucidation of hereditary morphological abnormalities in humans to establish their treatments and diagnoses.

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The nucleotide sequence of mouse Desert hedgehog gene registered under the accession No. “X76292” in “GenBank,” a necleic acid database by National Institute of Health, USA.
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Hammerschmidt, M. et al., “The World According to Hedgehog,”Trends in Genetics, 13:14-21 (1997).
The nucleotide sequence registered under the accession No. “AA064660” in “GenBank,” a nucleic acid database by National Institute of Health, USA.
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Abstract of XP 002079893, Drummond, “Human desert hedgehog,” (1996).

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